Drug Delivery Letters - Volume 12, Issue 4, 2022

Background: During the development of the new formulations, the hydrophobic drugs face many problems leading to poor water solubility and problems related to bioavailability. Topical drug delivery is a popular and unique process that directs the action of various drugs on the skin for the treatment and diagnosis of various diseases and disorders such as urticaria, inflammation, rheumatism, etc. This topical release system Read More

Background: Cancer is a leading cause of mortality. A vast number of conventional chemotherapeutic agents are being used to treat cancer; however, these conventional chemotherapeutic agents kill both tumor and healthy cells. Introduction: Cancer immunotherapy has gained tremendous attention and is being researched today to treat cancer. In the case of immunotherapy, the therapeutic techniques target o Read More

Background: The pulmonary route of administration has shown viability and effectiveness in local and systemic delivery, as a non-invasive method, not only for active pharmaceutical ingredients but also for genes, proteins, and enzymes for pulmonary and non-pulmonary diseases. Objectives: Nanoparticulate systems such as liposomes, solid lipid nanoparticles, nanostructured lipid carriers, emulsions, nanosuspensions, polymer Read More

Objective: The present study was designed to isolate, characterize, formulate, and evaluate the disintegration properties of banana starch in dispersible Lornoxicam tablet formulation. Methods: The alkaline extraction method used sodium hydroxide as a lye solution to isolate starch from unripe banana fruit. Starch was subjected to characterization for physicochemical properties, viscosity and flow properties, Fourier-trans Read More

Background: Microspheres are controlled drug delivery systems (CDDS) due to their potential to encapsulate various drugs, nucleic acids, and proteins. Their benefits include greater biocompatibility, increased bioavailability, and controlled release. Presently, existing antiulcer agents suffer from severe side effects, which has restricted their utility and encouraged the requirement of a harmless and proficient new antiulcer a Read More

Background: Amidst levodopa being considered as the “Gold standard” in the treatment of Parkinson’s disease (PD), it still has critical therapeutic issues with its dose regimen and dosage forms leading to severe adverse drug effects, decreased drug efficacy during chronic use, and requires an enforced “drug holiday” in PD patients. Hence, in this study, we designed a novel levodopa and carbidopa water-in-oil-in-water (w/o/w) f Read More