Current Topics in Medicinal Chemistry - Volume 25, Issue 2, 2025

Cardiovascular disorders develop the highest rates of mortality and morbidity worldwide, emphasizing the need for novel pharmacotherapies. The Chinese medicinal plant S. baicalensis has a number of major active components, one of which is called baicalin. According to emerging research, baicalin reduces chronic inflammation, immunological imbalance, lipid metabolism, apoptosis, and oxidative stress. Baicalin improves en Read More

Introduction: Ginseng, a perennial herb belonging to the Araliaceae family, is renowned for its traditional and folk uses. The Panax ginseng C.A. Meyer species is predominantly found in Asian countries, including Japan, China, and Korea.Materials and Methods: This manuscript offers valuable insights into the cultivation, collection, morphology, phytochemistry, pharmacological properties, and clinical studies of Ginseng. The dat Read More

IntroductionThe mutual activations of multiple signaling pathways are the key factors in the development and progression of myocardial cell injuries.ObjectivesThis research aimed to compare the different degrees of myocardial injury after coronary stenting, permanent pacemaker implantations, or cardiac radiofrequency ablation and to investigate the effects of the mutual activation of TNF-α/NF-κB, TLR2/TLR4, and Read More

BackgroundEpilepsy remains the most common and chronic disorder demanding long-term management. The impact of epilepsy disease is a cause of great concern and has resulted in efforts to develop treatment for epilepsy. It occurs due to an increase in neuronal excitability produced by changes affecting the voltage-dependent properties of Voltage-gated Sodium Channels (VGSCs).Materials and MethodsWeka, a popul Read More

IntroductionIron oxide nanoparticles demonstrate tremendous potential in preserving the ecological balance of the environment since they act as antimicrobial agents and efficient photocatalysts. However, environmental sustainability has challenged the synthesis protocols of nanomaterials.MethodsThis study compares the green synthesis method with the scalable chemical synthesis method. In this work, Iron Read More