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Role of the p53/miR-34a/SIRT1 Feedback Loop in Metformin-induced Radiosensitivity of Colorectal Cancer Cells
Authors: Ensiyeh Bahadoran, Yazdan Zafari, Ali Homaei, Manijeh Jalilvand and Sahar MoghbelinejadAvailable online: 04 February 2025More LessIntroduction Metformin induces radiation sensitivity in cancer cells, including colorectal cancer cells; however, the exact molecular mechanisms underlying its radiosensitive effects are not yet known. In this study, we investigated the role of the p53/miR-34a/SIRT1 pathway in the radiosensitivity of colon cancer cells. Methods The study was carried out from 2020 to 2022 at the Qazvin University of Medical Science' Read More
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Enhancing Ketoprofen Solubility: A Strategic Approach Using Solid Dispersion and Response Surface Methodology
Authors: Devika Tripathi, Dinesh Kumar Sharma and Jagannath SahooAvailable online: 24 October 2024More LessBackground In the pharmaceutical sciences, the solubility profile of therapeutic molecules is crucial for identifying and formulating drugs and evaluating their quality across the drug discovery pipeline based on factors like oral bioavailability, metabolic transformation, biodistribution kinetics, and potential toxicological implications. The investigation aims to enhance the solubility parameters of ketoprofen (BCS-II class) Read More
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Preclinical Aspects of [89Zr]Zr-DFO-Rituximab: A High Potential Agent for Immuno-PET Imaging
Available online: 24 October 2024More LessBackground An early diagnosis of cancer can lead to choosing more effective treatment and increase the number of cancer survivors. In this study, the preparation and preclinical aspects of [89Zr]Zr-DFO-Rituximab, a high-potential agent for PET imaging of Non-Hodgkin Lymphoma (NHL), were evaluated. Methods DFO was conjugated to rituximab monoclonal antibody (mAb), and DFO-rituximab was successfully labeled with zirc Read More
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