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The Central Composite Design and Artificial Neural Network Coupled with Genetic Algorithm in Optimization and Modeling of the Radiolabeling Process of 177Lu-hydroxyapatite as a Potential Radiosynovectomy Agent
Available online: 03 March 2025More LessIntroduction A promising material used in radiation synovectomy of small joints is hydroxyapatite, labeled with 177Lu. During the design and production of radiopharmaceuticals, the condition of the radiolabeling process directly influences the radiochemical yield and consequently the quality of the final product so this process necessitates precise optimization. Methods In this investigation, a central composite design ba Read More
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Mitigation of Radiation-induced Acute Hematopoietic System and Intestine Injury by Resveratrol-loaded Polymeric Nanoparticles after Whole Body Irradiation in Mice
Authors: Mohammad Mohammadi, Amir Kiani, Faranak Aghaz, Elham Arkan, Khodabakhsh Rashidi and Masoud NajafiAvailable online: 12 February 2025More LessIntroduction Radiation-induced damage to the hematopoietic and gastrointestinal systems, especially the intestine, is a major concern for individuals exposed to whole-body radiation during an accident. Resveratrol has shown potential in mitigating radiation-induced toxicity, but its efficacy may be limited by its low bioavailability. In this study, we aimed to evaluate the effectiveness of resveratrol-loaded polymeric-b Read More
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Role of the p53/miR-34a/SIRT1 Feedback Loop in Metformin-induced Radiosensitivity of Colorectal Cancer Cells
Authors: Ensiyeh Bahadoran, Yazdan Zafari, Ali Homaei, Manijeh Jalilvand and Sahar MoghbelinejadAvailable online: 04 February 2025More LessIntroduction Metformin induces radiation sensitivity in cancer cells, including colorectal cancer cells; however, the exact molecular mechanisms underlying its radiosensitive effects are not yet known. In this study, we investigated the role of the p53/miR-34a/SIRT1 pathway in the radiosensitivity of colon cancer cells. Methods The study was carried out from 2020 to 2022 at the Qazvin University of Medical Science' Read More
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