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Volume 18, Issue 3
  • ISSN: 1874-4710
  • E-ISSN: 1874-4729

Abstract

Introduction

Radiation-induced damage to the hematopoietic and gastrointestinal systems, especially the intestine, is a major concern for individuals exposed to whole-body radiation during an accident. Resveratrol has shown potential in mitigating radiation-induced toxicity, but its efficacy may be limited by its low bioavailability. In this study, we aimed to evaluate the effectiveness of resveratrol-loaded polymeric-based nanocapsules in mitigating radiation-induced injury in the hematopoietic system and intestine after whole-body exposure to radiation.

Methods

Sixty male mice were randomly divided into four groups: control, radiation (single dose of 7.2 Gy of X-ray) only, resveratrol-loaded polymeric-based nanocapsules (RES-ACN) only, and radiation plus RES-ACN. Mice were exposed to a single dose of 7.2 Gy of X-ray radiation. RES-ACN was administered to the mice starting 24 h after irradiation up to day 7 post-irradiation. Then, blood and tissue samples were collected for complete blood count and histopathological and biochemical evaluation. Survival analyses were also conducted.

Results

The findings showed that RES-ACN significantly mitigated radiation-induced injury to the hematopoietic system and intestine. The histopathological evaluation showed the mitigation of villi shortening, inflammation, and mucous layer thickness following treatment with RES-ACN. Biochemical evaluation also demonstrated a significant increase in the activity of glutathione peroxidase and superoxide dismutase and a significant reduction in the concentrations of malondialdehyde and nitric oxide. Treatment with RES-ACN also showed a significant improvement in some of the blood parameters and increased survival compared to radiation only.

Conclusion

The findings suggest that resveratrol-loaded polymeric-based nanocapsules can be an effective approach to mitigate radiation-induced damage to the hematopoietic system and intestine after whole-body exposure to X-ray radiation in mice. Further research is needed to explore the optimal dose and timing of resveratrol administration and to investigate the potential for clinical translation of this approach.

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2025-06-20

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Mitigation of Radiation-induced Acute Hematopoietic System and Intestine Injury by Resveratrol-loaded Polymeric Nanoparticles after Whole Body Irradiation in Mice
Current Radiopharmaceuticals 18, 182 (2025); https://doi.org/10.2174/0118744710335266250206060602
/content/journals/crp/10.2174/0118744710335266250206060602
/content/journals/crp/10.2174/0118744710335266250206060602
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  • Article Type:     Research Article
Keyword(s): hematopoietic system; intestine; nanoparticle; oxidative stress; Radiation mitigation; resveratrol

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