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Current Radiopharmaceuticals - Current Issue
Volume 17, Issue 4, 2024
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In Situ Photo Responsive Biodegradable Nanoparticle Forming Intrauterine Implant for Drug Delivery to Treat Ovarian Diseases: A Rationale-based Review
Ovarian disease constitutes various types of endocrine disorders, such as polycystic ovarian syndrome (PCOS), ovarian cancer, premature ovarian failure, ovarian endometriosis, and ovarian cysts. The prevalence of ovarian-related diseases is highly vulnerable in the world. The utility of various drug delivery systems for ovarian diseases has resulted in varied success. Moreover, most of them lead to severe adverse effects and a Read More
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Optimal Indications of Radioimmunotherapy in Nuclear Medicine: A Mini-Review
Immunotherapy has emerged as a very considerable and potent therapeutic method in which immune inhibitors have gained a lot of attention in the curative field of various cancers. Under certain circumstances, when radiotherapy is accompanied by immunotherapy, the efficacy of the therapeutic procedure increases. Irradiated tumor cells follow a pathway called immunogenic cell death, which targets tumor associate Read More
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Theranostic and Combined Approaches Exploiting Multifunctional Gold Nanoclusters in Tumoral Ecosystems: A Paradigm Shift in Precision Oncology
Authors: Shatrudhan Prajapati, Shikha Yadav and Javed KhanMalignant tumors pose a significant threat to human life and well-being because of their rising occurrence and size. The current treatment methods and diagnostic techniques employed in clinical practice are inadequate for effectively treating tumors. Fluorescence, photothermal effects, radiosensitization, and biocompatibility are only a few instances of the unique photonic and physicochemical properties exhibited. Gold n Read More
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RGIE: A Gene Selection Method Related to Radiotherapy Resistance in Head and Neck Squamous Cell Carcinoma
Authors: Qingzhe Meng, Dunhui Liu, Junhong Huang, Xinjie Yang, Huan Li, Zihui Yang, Jun Wang, Wanpeng Gao, Yahui Li, Rong Liu, Liying Yang and Jianhua WeiBackground: Head and Neck Squamous Cell Carcinoma (HNSCC) is a malignant tumor with a high degree of malignancy, invasiveness, and metastasis rate. Radiotherapy, as an important adjuvant therapy for HNSCC, can reduce the postoperative recurrence rate and improve the survival rate. Identifying the genes related to HNSCC radiotherapy resistance (HNSCC-RR) is helpful in the search for potential therapeuti Read More
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177Lu-PSMA-617 Radioligand Treatment in Elderly Patients with Metastatic Castration-resistant Prostate Cancer: Therapeutic Efficacy and Safety Assessment
Authors: Ertan Sahin, Umut Elboga, Ufuk Cimen, Merve Okuyan and Yusuf Burak CayirliObjective: This study aimed to evaluate the therapeutic efficacy and safety of 177Lutetium-Prostate Specific Membrane Antigen (177Lu-PSMA-617) radioligand treatment (RLT) in metastatic castration-resistant prostate cancer (mCRPC) patients with aged older than 75 years. Methods: A total of 37 patients with mCRPC aged older than 75 years treated with 177Lu- PSMA-617 were included in this study. Pre-therapy and post-thera Read More
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The Diverse Utility of Contrast Media Delivery and Dosing During Computed Tomography: An International Assessment of Knowledge and Practices
Authors: Mohammad Rawashdeh, Daniah Kashabash, Praveen Kumar and Charbel SaadeBackground: Despite the escalated production rate, the Iodinated Contrast Media (ICM) shortage continues, and demand outweighs supply. Aim: The aim of this study is to investigate the knowledge and practice of ICM delivery in computed tomography (CT) among radiographers and radiologic technologists worldwide. Methods: An IRB-approved cross-sectional survey used Google Forms for data collection. It involved Read More
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Hypofractionated Radiation Therapy Suppresses Radioresistance in U87 Human Glioma Cells by Inhibiting Yap1 and Hsp90 Proteins
Background: Radiotherapy plays a vital role in the management of high-grade gliomas. However, the radio resistance of glioma cells limits the effect of radiation and drives recurrence inside the irradiated tumor volume leading to poor outcomes for patients. Methods: High-grade glioma cell radioresistance significantly contributes to radiotherapy failure, highlighting the importance of identifying predictive biomarkers for radi Read More
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An 18F-MD-PSMA (Multi-dentate PMSA Imaging Agent) PET/CT in Prostate Cancer Relapse: Results of a Retrospective Trial
Authors: Hongliang Fu, Sheng Liang, Miaomiao Xu, Jun Guo, Qiang Liu, Jian Kang, Linlin Zhang, Zihao Liu, Lin Ding, Yufei Ma, Bin Yang, Xudong Yao, Jun Qi, Hui Wang and Yongquan CaiPurpose: This study aimed to evaluate the performance of 18F-MD-PSMA PET/CT in patients previously treated for prostate cancer by either surgery or therapy, but later relapsed biochemically. Methods: This retrospective study enrolled 213 patients in sequence previously treated for prostate cancer by either surgery or therapy, but later PSA relapsed. A total of 191 of these 213 patients were included in this analysis. Read More
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