Current Psychopharmacology - Volume 5, Issue 1, 2016

Background: Vitamin D deficiency has been identified as a global problem and about 14% of the world population has inadequate vitamin D levels. It is a neuroactive com- pound, a prohormone, and highly active in a variety of body tissues including the brain. The role of vitamin D in normal bone physiology, the pathogenicity of rickets, osteomalacia, and osteo- porosis has been long recognized. However, in recent years a bo Read More

Objective: Schizophrenia is usually characterized by abnormal social behavior, lack of insight, and positive and negative symptoms. While there is increasing evidence that atypical antipsychotics have advantages over conventional ones, few long-term studies have directly compared the atypical antipsychotics with each other. Therefore, in the present as- sessment, the efficacy and safety of aripiprazole had been compar Read More

Objectives: Since according to some studies, atypical antipsychotics were con- nected with better results and lesser adverse effects in comparison with conventional ones, at the present time the later kind of medications are the preferred category of antipsychotics in clinical management of schizophrenia. But such a maneuver has not decreased hitherto the dilemma of treatment -resistance. The objective of the present ass Read More

Objective: A number of studies have shown that olanzapine and risperidone are more clinically effective than other antipsychotics. Consequently, if a treatment-resistant schizophrenic patient has not received them so far in their treatment history, it would be a sensible choice to use these drugs in treatment before beginning a clozapine regimen. In the present investigation the efficacy and safety of these two atypical antipsychot Read More

Background: Clozapine induced granulocytopenia has gained wide attention and effec- tive monitoring has been able to prevent a number of untoward deaths. However, other myelodys- plasias induced by Clozapine are still unrecognized and unreported. Another clinical complication of Clozapine is eosinophilia. However, this entity is unrecognized as the focus is mostly on granulocytopenia and neutropenia. Objective: To Read More

Background: Although methamphetamine (MA) use during adolescence has be- come associated with increased aggressive, violent, and criminal behavior in humans, there is a relative lack of empirical research substantiating any direct link between acute and re- peated exposure to the drug, and heightened aggression. There is also little known about ex- posure during adolescence and subsequent effects on aggression in adul Read More

Background: Previous cross-sectional studies have concluded that the positive relationship between vitamin D status and cognition may reflect reverse causality, that is, low vitamin D status results from cognitive decline, associated behaviours and comorbidities, and not the reverse. The present study therefore investigated relationships between total 25-0H-D (25-0H-D3 plus 25-0H-D2) and 15 integrated scores of cognitio Read More

Background: Quetiapine - an antipsychotic multidrug resistance protein 1 (MDR-1) substrate - has a large interindividual variability in its pharmacokinetics. Objective: In order to unravel the true effect of MDR-1 activity in the plasma levels of quetiapine, we studied the bioavailability of quetiapine in healthy subjects with different transporter activity. Method: Fifty-four Mexican mestizo healthy subjects, both male and fem Read More