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2000
Volume 5, Issue 1
  • ISSN: 2211-5560
  • E-ISSN: 2211-5579

Abstract

Background: Previous cross-sectional studies have concluded that the positive relationship between vitamin D status and cognition may reflect reverse causality, that is, low vitamin D status results from cognitive decline, associated behaviours and comorbidities, and not the reverse. The present study therefore investigated relationships between total 25-0H-D (25-0H-D3 plus 25-0H-D2) and 15 integrated scores of cognition and mood cognitively-normal, healthy elderly subjects. Methods: The study was cross-sectional and based in Adelaide, South Australia (lat: 34.93°S) during summer months of 2008. Participants, from the 0lder People, 0mega-3 and Cognitive health (EP0CH) Study (ACTRN12607000278437), were community-dwelling (N=387), 65 to 90 years (mean 73.1), 54% female and cognitively normal at baseline (MMSE>24). Blood sampling, cognition and mood testing at a single timepoint occurred from January to April. Participants were characterised by multiple biometric and clinical measures and bloods were analysed for 25-0H-D3 and 25-0H-D2, homocysteine, C-reactive protein and malondialdehyde. Results: Based on a cut-off of 75 nM 25-0H-D, 44% of participants were considered deficient. Fully adjusted models controlling for all parameters significantly associated with vitamin D status or cognition/mood measure demonstrated that 25-0H-D was significantly related to one cognition (Reasoning Speed, p=0.03) and two mood measures (General Positive Affect, p=0.02; Attentiveness, p=0.02). Additional relationships were present for sub-populations based on gender, vitamin D sufficiency and AP0E genotype. Conclusion: The positive relationships between vitamin D status and selected brain functions observed within this cognitively healthy cohort support a causal, protective role of vitamin D in brain function however, clini- cal substantiation is required.

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/content/journals/cpsp/10.2174/2211556005666160325202613
2016-04-01
2025-07-03
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