Clozapine Induced Eosinophilia in a Case of Schizoaffective Disorder

Background: Clozapine induced granulocytopenia has gained wide attention and effec- tive monitoring has been able to prevent a number of untoward deaths. However, other myelodys- plasias induced by Clozapine are still unrecognized and unreported. Another clinical complication of Clozapine is eosinophilia. However, this entity is unrecognized as the focus is mostly on granulocytopenia and neutropenia. Objective: To describe a case of Clozapine induced eosinophilia without any other clinical or biochemical abnormali- ties induced by Clozapine. Methodology: The file records of a patient with Schizoaffective disorder who developed eosinophilia while receiving Clozapine were studied and analyzed. Results: The patient with Schizoaffective disorder who was on Clozapine with stringent monitoring developed eo- sinophilia with eosinophil counts rising up to 2850, with a fall in neutrophil counts up to 2320, all of which was re- versed after stopping Clozapine. Conclusion: Clozapine induced eosinophilia should also be considered as one of the important side effects along with neutropenia and leukopenia. Along with neutropenia and leukopenia it might be a manifestation of undergoing immunological abnormality associated with Clozapine.