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Current Psychopharmacology - Online First
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Neuroinflammation in the Genesis of Epilepsy
Authors: Rashmi Rani, Sarvesh Paliwal and Sumitra NainAvailable online: 14 February 2025More LessEpilepsy is the second most typical chronic disorder, described by recurrent seizures and uncontrolled electrical signaling from neurons in the cerebral cortex. Stimulated astrocytes, along with microglia, promote cytokines that cause neuroinflammation, leading to a chain reaction of subsequent steps involving neurons as well as endothelial cells along the blood-brain barrier. Inflammation in the brain’s neural network Read More
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Advancing Alzheimer's Treatment: Unleashing the Power of Donanemab and Quantum Computing for Enhanced Patient Outcomes
Authors: Afzal Hussain and Ashfaq HussainAvailable online: 14 January 2025More LessDonanemab is the first antibody to target pyroglutamate-modified amyloid-beta in Alzheimer's disease selectively; thus, it represents a significant breakthrough in disease-modifying treatments. Importantly, its mechanism of action encourages adequate clearance of plaques and does not even worsen outcomes for early-stage patients, in contrast to previous treatments that did not promote clearing for plaques or even worsene Read More
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Potential of Andrographolide and Andrographis paniculata Extracts for the Management of Diabetes-associated Psychopathologies: Current Status
Authors: Shyam Sunder Chatterjee, Sweta Rani, Riya Sah and Ajit Kumar ThakurAvailable online: 27 December 2024More LessDespite the availability of numerous anti-hyperglycemic and psychoactive drugs, and diverse therapeutic modalities, prevention and cure of diabetes-associated mental health problems continue to be a major challenge for medical practitioners. Considerable efforts have been made in many research laboratories, including ours, to identify the bioactive of traditionally known medicinal or food plants to identify their bioac Read More
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Metaforest Algorithm Insights: Predictors of Nocebo Response in ADHD
Authors: Mireia Porta, Maggie Barcheni, David Ramírez-Saco, Ruth Cunill, Magí Farré, Marc Saez, Beatriz López and Xavier CastellsAvailable online: 26 December 2024More LessBackground Predicting the nocebo response in randomized controlled trials (RCTs) is crucial as it can help minimize its influence and improve the evaluation of the side effects of interventions for ADHD. The aim of this study is to determine the effect of covariates related to study design, intervention, and patients’ characteristics on the nocebo response in patients with Attention Deficit Hyperactivity Disorder (ADHD) using Read More
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Marine Natural Products as Novel Treatments for Alzheimer's Disease
Authors: Ekta Khare, Zeeshan Fatima and O.P. TiwariAvailable online: 13 December 2024More LessAlzheimer's disease is distinguished by gradual changes in behavior because of the aggregation of β-amyloid and τ protein that blocks the signal transduction pathway. It is one of the major problems in the current scenario. It mainly occurs after the age of 60 and eventually leads to memory loss. Nonetheless, medicinal plants have therapeutic potential to improve many diseases. Medicinal drugs with their phytoconstituents m Read More
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The Present Difficulties and Potential Benefits of Dopaminergic Agents in Parkinson's Disease Treatment
Available online: 12 November 2024More LessParkinson's disease (PD) is a progressive neurological condition characterized by bradykinesia, rigidity, tremors, and impaired balance, among other motor impairments. The issue arises from dopaminergic neurons located in the spinal column of the brain. This research report examines the therapeutic potential of dopaminergic medications in the management of Parkinson's disease. The central concept of Parkinson's diseas Read More
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