Current Protein and Peptide Science - Volume 24, Issue 8, 2023

Hyperphosphatemia is independently linked with vascular calcification, cardiovascular disease, bone-mineral disease, progression of renal insufficiency, and all-cause mortality in chronic kidney disease (CKD) and end-stage renal disease (ESRD). The emerging importance of fibroblast growth factor-23 (FGF-23) and its co-factor Klotho play very important roles as phosphaturic hormones; however, phosphate levels rise Read More

Antimicrobial peptides (AMPs) are widely sourced and have a variety of biological activities such as broad-spectrum antibacterial, antiviral, and anticancer. Since AMPs are less likely to cause drug resistance, they are expected to be an alternative to antibiotics. Compared with natural extraction and chemical synthesis methods, producing AMPs using genetic engineering is a hot research topic for the large-scale produc Read More

New Delhi Metallo-β-lactamase is an enzyme produced by gram-negative bacteria which has become one of the global concerns for physicians to treating the infection. These Metallo- β-lactamase are capable of catalyzing the hydrolysis of almost all β-lactam antibiotics, endangering infection treatment. Substitution of single or multiple amino acids results in new NDM variants. Forty NDM variants have been identified in differen Read More

Aims: To reveal the prognostic role of unfolded protein response (UPR) -related genes in hepatocellular carcinoma (HCC). Background: Hepatocellular carcinoma is a genetically heterogeneous tumor, and the prediction of its prognosis remains a challenge. Studies elucidating the molecular mechanisms of UPR have rapidly increased. However, the UPR molecular subtype characteristics of the related genes in HCC Read More

Background: The oral cancer microenvironment plays an important role in the development and progression of the disease which depicts the heterogeneous nature of diseases. Several cellular and non-cellular factors, including dipeptides, have been reported to drive tumor progression and metastasis. Among various secreted molecules in the tumor microenvironment, prolylhydroxyproline (Pro-Hyp) is a collagen-degrad Read More