Current Pharmacogenomics and Personalized Medicine (Formerly Current Pharmacogenomics) - Volume 21, Issue 1, 2024

Background: The field of pharmacogenomics investigates the ways in which genes impact the body's reaction to drugs. Through the integration of genetics and medical knowledge, it is possible to develop individualised and efficient therapies that are based on genetic profiles. Specifically, this evaluation focuses on three aspects: 1) Finding molecular targets and gaining a grasp of their structures is the first step. 2) Using pharm Read More

Introduction: Prostate cancer is the second most frequent malignancy after lung cancer among men, accounting for 7% of new cancers diagnosed around the world (15% in developed regions). This disease has become more prevalent in Iran over the past few decades, moving up the rankings from 13th in 1986 to 4th in 2005 and finally reaching third place in a recent study in 2016. The purpose of this study is to investigate the Read More

Background: Clinical trial participants play a crucial role in advancing medical research, and the data generated from their participation can indeed be invaluable for future studies. However, the reuse of genetic or clinical research data comes with ethical challenges that need careful consideration. Here are some of the key ethical issues associated with the re-use of such data: Reusing data without clear informed con Read More

Aim: To analyse the nsSNPs associated with the human WWOX gene using bioinformatics tools. Background: WW domain-containing oxidoreductase (WWOX) is a protein-coding gene that controls several biological processes, including RNA splicing, transcription, and protein degradation. The modification in the WWOX gene is associated with osteopenia, metabolic syndrome, gestational diabetes, tumour progression, and disru Read More