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Current Pharmacogenomics and Personalized Medicine (Formerly Current Pharmacogenomics) - Online First
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Investigation of Genetic Variants of Alox12 (rs9904779) Gene in Dental Caries
Authors: Nihala Sidhic and Usha SubbiahAvailable online: 27 December 2024More LessBackground Dental caries is a biofilm-mediated disease driven by dietary sugars that reduce pH and promote cariogenic microorganisms. Caries result from a complex interplay of behaviour, environmental, genetic, and physiological factors, with the immune response and bacterial activity contributing to enamel demineralization and cavity formation. Genetic factors, such as SNPs, also influence caries susceptibility, impacti Read More
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Leveraging Drug-Gene Interaction Information for Personalized Hypertension Drug Molecule Discovery
Authors: Odifentse M. Lehasa and Uche A.K. Chude-OkonkwoAvailable online: 13 December 2024More LessAims To examine whether novel lead hypertension molecules can be used in the personalized treatment of hypertension. Background Hypertension is a modifiable condition that affects over 1 billion adults worldwide. Maintaining a healthy blood pressure is vital for overall health, especially given that hypertension is a primary risk factor for developing cardiovascular conditions. However, some individuals have resistant hypertensi Read More
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First Insight into the Mutational Landscape of BRAF and KRAS Genes in Lung Cancer Patients from Morocco
Available online: 03 December 2024More LessBackground Lung cancer (LC) is a lethal malignancy with a late diagnosis and poor prognosis. During the last decade, the identification of oncogenic driver alterations has noticeably changed the therapeutic landscape and contributed to the emergence of the “oncogene addiction” concept and precision medicine in oncology. Among these alterations, the spotlight has turned to driver mutations in the KRAS and BRAF genes, whic Read More
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