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Current Pharmacogenomics and Personalized Medicine (Formerly Current Pharmacogenomics) - Online First
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Exploring the Potent Anticancer Activity of Novel Phytoconstituent Derived from Zanthoxylum Nitidum Using an In-Silico Approach
Authors: Sonali S. Shinde, Sachin S. Bhusari and Pravin S. WakteAvailable online: 17 March 2025More LessBackground Cancer is one of the serious health issues and the leading cause of mortality worldwide. Several studies have demonstrated that the overexpression of growth factors and receptors, the triggering of oncogenes, and the deactivation of tumor suppressor genes are the main causes of aggressive and resistant forms of cancer. The epidermal growth factor receptor (EGFR) is a receptor that medications target for canc Read More
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The Genetic Variations Affecting the Pathophysiology and Pharmacological Treatment of Type 2 Diabetes Mellitus
By Igor KravetsAvailable online: 10 March 2025More LessType 2 diabetes mellitus is one of the leading causes of morbidity and mortality in the world. The two main components of the mechanism underlying T2DM are insulin resistance and impaired insulin secretion. The current algorithmic approach to the treatment of the disease does not take the individual genetic makeup of patients into consideration. However, multiple gene variants affect the efficacy and metabolism of Read More
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Effect of Phytochemical Extracts on the Inflammatory Pathway
Authors: Aziz Alkhaddour and Elena Vladimirovna MashkinaAvailable online: 04 February 2025More LessBackground The research highlights the effect of phytochemical compounds on the correlation of cellular pathways of cytokines and antioxidant enzymes at the molecular levels. Objective This work examines the effects of phytochemical substances on the expression of (IL1β and IL6, IL10) genes present in different amounts in garlic, grape seed, and pomegranate extracts in various amounts. Within the same framework, ge Read More
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Investigation of Genetic Variants of Alox12 (rs9904779) Gene in Dental Caries
Authors: Nihala Sidhic and Usha SubbiahAvailable online: 27 December 2024More LessBackground Dental caries is a biofilm-mediated disease driven by dietary sugars that reduce pH and promote cariogenic microorganisms. Caries result from a complex interplay of behaviour, environmental, genetic, and physiological factors, with the immune response and bacterial activity contributing to enamel demineralization and cavity formation. Genetic factors, such as SNPs, also influence caries susceptibility, impacti Read More
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Leveraging Drug-Gene Interaction Information for Personalized Hypertension Drug Molecule Discovery
Authors: Odifentse M. Lehasa and Uche A.K. Chude-OkonkwoAvailable online: 13 December 2024More LessAims To examine whether novel lead hypertension molecules can be used in the personalized treatment of hypertension. Background Hypertension is a modifiable condition that affects over 1 billion adults worldwide. Maintaining a healthy blood pressure is vital for overall health, especially given that hypertension is a primary risk factor for developing cardiovascular conditions. However, some individuals have resistant hypertensi Read More
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First Insight into the Mutational Landscape of BRAF and KRAS Genes in Lung Cancer Patients from Morocco
Available online: 03 December 2024More LessBackground Lung cancer (LC) is a lethal malignancy with a late diagnosis and poor prognosis. During the last decade, the identification of oncogenic driver alterations has noticeably changed the therapeutic landscape and contributed to the emergence of the “oncogene addiction” concept and precision medicine in oncology. Among these alterations, the spotlight has turned to driver mutations in the KRAS and BRAF genes, whic Read More
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