- Home
- A-Z Publications
- Current Pharmaceutical Design
- Previous Issues
- Volume 11, Issue 10, 2005
Current Pharmaceutical Design - Volume 11, Issue 10, 2005
Volume 11, Issue 10, 2005
-
-
Editorial [Hot Topic: Spinal Cord Injury and Repair - Part I (Executive Editor: Weihong Pan)]
By Weihong PanSpinal cord injury (SCI) is followed by a series of dynamic changes in the injured spinal cord and the environment that influence the extent of structural and functional recovery. All therapeutic interventions work toward one goal: to restore balance in the spinal cord by promoting regenerative pathways and depressing the degenerative factors (Fig. 1). Caution comes from awareness that acute effects are not alwa Read More
-
-
-
Neuroprotection and Regeneration Strategies for Spinal Cord Repair
Authors: Eve C. Tsai and Charles H. TatorThe journey toward a cure for spinal cord injury (SCI) has taken many paths. In this article, we review these paths, and highlight the clinical applications of these experimental repair strategies. Initial strategies involved attempts at neuroprotection with steroids and other anti-inflammatory drugs. Other anti-ischemia treatments, agents to eliminate the damage from excitotoxicity, and anti-apoptotic agents wer Read More
-
-
-
Inflammatory-Mediated Injury and Repair in the Traumatically Injured Spinal Cord
Authors: T. B. Jones, E. E. McDaniel and P. G. PopovichSpinal cord trauma activates the immune system and elicits leukocyte recruitment to the site of injury. This increase in immunological activity contributes to acute lesion expansion over a period of days to weeks following the initial trauma. At the same time, inflammatory cells and mediators facilitate endogenous repair processes such as axonal sprouting and remyelination. Thus, to be effective, therapies that targe Read More
-
-
-
Cell Elimination as a Strategy for Repair in Acute Spinal Cord Injury
More LessFollowing injury, as part of the wound-healing process, cell proliferation occurs mostly to replace damaged cells and to reconstitute the tissue back to normal condition/function. In the spinal cord some of the dividing cells following injury interfere with the repair processes. This interference occurs at the later stages of wound healing (the third week after injury) triggering chronic inflammation and progressive tissue decay th Read More
-
-
-
Targeting Neurite Growth Inhibitors to Induce CNS Regeneration
Authors: Abba J. Kastin and Weihong PanProminent among the several endogenous inhibitors known to limit recovery and plasticity after CNS injury are Nogo (neurite outgrowth inhibitor) and MAG (myelin associated glycoprotein). The effects of these inhibitors on axonal regeneration can be reduced by administration of specific antagonists, some of which are commercially available for experimental investigation. There are three aspects of therapeutic manipulat Read More
-
-
-
Plasticity and Therapeutic Potential of Mesenchymal Stem Cells in the Nervous System
Authors: Donald G. Phinney and Iryna IsakovaMesenchymal stem cells resident in adult bone marrow are best characterized by their capacity to differentiate into connective tissue cell types such as adipocytes, chondrocytes, osteoblasts and hematopoiesis-supporting stroma. Accordingly, these cells are being evaluated in human clinical trials for efficacy in treating genetic diseases of bone, to speed hematopoietic recovery after bone marrow transplantation and reduce t Read More
-
-
-
Strategies to Create a Regenerating Environment for the Injured Spinal Cord
Authors: Shulin Xiang, Weihong Pan and Abba J. KastinSpine cord injury (SCI) leads to devastating functional loss below the level of injury. Partially explained by the presence of a non-permissive environment, the injured spinal cord does not mount adequate regeneration to reestablish functional connections. Therefore, it is important to identify the cellular and molecular factors and their interactions that affect axonal regeneration within the changed environment. This re Read More
-
-
-
Innate Immunity and the Heart
Authors: Stefan Frantz, Johann Bauersachs and Ralph A. KellyThe immune system of higher vertebrates consists of two components: the innate and adaptive immunity. While the adaptive immune system relies on somatically generated and clonally selected antigen receptors, the innate immune system detects the presence of pathogens by their evolutionarily highly conserved, relatively invariant structural motifs. Interestingly, recent data suggest that activation of the innate imm Read More
-
-
-
The Reno-Protective Effect of the Dual Blockade of the Renin Angiotensin System (RAS)
Authors: Jose Luno, Manuel Praga and Soledad G. de VinuesaHypertension and proteinuria are risk factors for renal disease progression. There is clear evidence that pharmacological blockade of the RAS with angiotensin converting enzyme inhibitors (ACEI) or angiotensin receptor blockers (ARB) reduces proteinuria and slows down the progression of renal disease in diabetic and non diabetic nephropathies, a beneficial effect not related to blood pressure control. However, not all patie Read More
-
-
-
Phospholipase A2 Inhibitors as Potential Anti-Inflammatory Agents
Authors: M. C. Meyer, P. Rastogi, C. S. Beckett and J. McHowatPhospholipase A2 (PLA2)-catalyzed hydrolysis of membrane phospholipids results in the stoichiometric production of a free fatty acid, most importantly arachidonic acid, and a lysophospholipid. Both of these phospholipid metabolites serve as precursors for inflammatory mediators such as eicosanoids or platelet-activating factor (PAF). Since it was initially discovered that non-steroidal anti-inflammatory drugs inhibit prost Read More
-
-
-
Targeting Kinin Receptors for the Treatment of Neurological Diseases
Authors: D. Rodi, R. Couture, B. Ongali and M. SimonatoKinins (bradykinin, kallidin and their active metabolites) are peptide autacoids with established functions in cardiovascular homeostasis, contraction and relaxation of smooth muscles, inflammation and nociception. They are believed to play a role in disease states like asthma, allergies, rheumatoid arthritis, cancer, diabetes, endotoxic and pancreatic shock, and to contribute to the therapeutic effects of ACE inhibitors in c Read More
-
-
-
The Role of Alterations in Arachidonic Acid Metabolism and Nitric Oxide Homeostasis in Rat Models of Diabetes During Early Pregnancy
Authors: A. Jawerbaum and E. GonzalezThe diabetic pathology induces reproductive abnormalities that enhance spontaneous abortion, congenital anomalies and neonatal morbidity/mortality rates, abnormalities that begin with an altered female gamete. In this review we focus on the damage induced by maternal hyperglycemia during ovulation, early embryo development, implantation and embryo organogenesis in experimental rat models of dia Read More
-
-
-
Opioids: Old Drugs for Potential New Applications
More LessOpioids are commonly used analgesics in clinical practice. Three opioid receptors (μ, δ and κ) that mediate opioid effects have been identified by molecular cloning. Each type of opioid receptors consists of subtypes of receptors as suggested by pharmacological studies. Although μ opioid receptors are the major receptor to mediate the analgesic effects of opioids, δ and κ receptors are also important in anti-nociception (fo Read More
-
Volumes & issues
-
Volume 31 (2025)
-
Volume 30 (2024)
-
Volume 29 (2023)
-
Volume 28 (2022)
-
Volume 27 (2021)
-
Volume 26 (2020)
-
Volume 25 (2019)
-
Volume 24 (2018)
-
Volume 23 (2017)
-
Volume 22 (2016)
-
Volume 21 (2015)
-
Volume 20 (2014)
-
Volume 19 (2013)
-
Volume 18 (2012)
-
Volume 17 (2011)
-
Volume 16 (2010)
-
Volume 15 (2009)
-
Volume 14 (2008)
-
Volume 13 (2007)
-
Volume 12 (2006)
-
Volume 11 (2005)
-
Volume 10 (2004)
-
Volume 9 (2003)
-
Volume 8 (2002)
-
Volume 7 (2001)
-
Volume 6 (2000)
Most Read This Month
Article
content/journals/cpd
Journal
10
5
false
en
