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- Volume 11, Issue 16, 2005
Current Pharmaceutical Design - Volume 11, Issue 16, 2005
Volume 11, Issue 16, 2005
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Experimental Antioxidant Biotherapy for Protection of the Vascular Wall by Modified Forms of Superoxide Dismutase and Catalase
More LessThe antithrombotic activities of superoxide dismutase and catalase are determined by their effects on reactive oxygen species. Modification of these enzymes with chondroitin sulphate enhances the effect due to accumulation of the derivatives on the surface of the vascular wall cells. We have shown that the effects of covalently modified biocatalysts exceed those of native enzymes, free chondroitin sulphate and their mix Read More
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Role of Anti-Oxidants in Atherosclerosis: Epidemiological and Clinical Update
Authors: A. Cherubini, G. B. Vigna, G. Zuliani, C. Ruggiero, U. Senin and R. FellinLow density lipoprotein (LDL) oxidative modification in the vascular wall seems to be a key factor in atherosclerosis development. Oxidised LDLs might recruit monocytes and favour their transformation into foam cells through a receptor-mediated intake (scavenger pathway). Moreover oxidised LDLs show cytotoxic potential which is probably responsible for endothelial cell damage and macrophage degeneration in the a Read More
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Oxidative Stress, Antioxidants and Neurodegenerative Diseases
Authors: I. Casetta, V. Govoni and E. GranieriIt is widely accepted that oxidative stress increases with age, and that age is a major risk factor for several neurodegenerative diseases such as Parkinson's disease and Alzheimer's disease. An inbalanced overproduction of reactive oxygen species can induce neuronal damage, leading to neuronal death by necrosis or apoptosis. Antioxidants are consequently considered to be a promising approaches to neuroprotection. Al Read More
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Oxidants in Asthma and in Chronic Obstructive Pulmonary Disease (COPD)
Authors: S. Psarras, G. Caramori, M. Contoli, N. Papadopoulos and A. PapiExperimental and clinical evidences suggest that oxidants play a role in the pathogenesis of respiratory disorders characterised by chronic airway inflammation such as asthma and chronic obstructive pulmonary disease (COPD). The respiratory system is chronically exposed to environmental pollutants, including oxidants. Exogenous sources of oxidants are particularly relevant to the pathogenesis of COPD, being cigarette smo Read More
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Management of the Menopausal Disturbances and Oxidative Stress
Authors: Francesco Pansini, Gioacchino Mollica and Carlo M. BergaminiWomen frequently seek gynaecologic medical advice at menopause and require pharmacologic interventions to control subjective vasomotor complaints and to prevent late severe organic complications, which may effect the genitourinary tract, the skeletal, the cardiovascular and the nervous system. Depending on the severity of the presentation and the involvement of additional systems beyond the reproductive tract Read More
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The Role and Modulation of the Oxidative Balance in Pregnancy
Authors: Carla Biondi, Barbara Pavan, Laura Lunghi, Sara Fiorini and Fortunato VesceOxidative processes exert a fundamental regulatory function during pregnancy. It depends on the influence of oxygen, nitric oxide, reactive oxygen species and reactive nitrogen species metabolic pathways upon the vascular changes in the maternal organism, as well as on the regulation of uterine and cervical tone throughout gestation and delivery. These functions are strictly linked with the mediators of the inflammatory p Read More
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Metallic Colloid Nanotechnology, Applications in Diagnosis and Therapeutics
Authors: Fabio Sonvico, Catherine Dubernet, Paolo Colombo and Patrick CouvreurIn recent years the fields of medicine and biology assist to an ever-growing innovation related to the development of nanotechnologies. In the pharmaceutical domain, for example, liposomes, polymer based micro and nanoparticles have been subjects of intense research and development during the last three decades. In this scenario metallic particles, which use was already suggested in the first half of the '80, are now ex Read More
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Triple Treatment with Octreotide, Galanin and Serotonin is a Promising Therapy for Colorectal Cancer
More LessIn patients with colorectal cancer, low levels of colonic somatostatin, galanin and serotonin have been found. Based on these findings, the effects of triple treatment with octreotide (a somatostatin analogue), galanin and serotonin on colorectal cancer has been studied. Triple therapy was found to reduce the volume and weight of both rat and human colon carcinoma in xenografts, apparently by necrosis, but also by reducing pr Read More
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Integrin Function and Signaling as Pharmacological Targets in Cardiovascular Diseases and in Cancer
Authors: E. Paulhe, S. Manenti, L. Ysebaert, R. Betous, P. Sultan and C. Racaud-SultanThe microenvironment is now considered as an important source of potential therapeutic targets in diverse pathologies. In cardiovascular diseases and in cancer, common processes involving stromal remodeling, cell invasion, and angiogenesis can promote progression of the pathology. At each step of the pathogenesis, cell adhesion needs to be modulated to allow adaptation of cell survival/motility/proliferation functions to the Read More
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Volumes & issues
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Volume 31 (2025)
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Volume 30 (2024)
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Volume 29 (2023)
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Volume 28 (2022)
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Volume 27 (2021)
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Volume 26 (2020)
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Volume 25 (2019)
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Volume 24 (2018)
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Volume 23 (2017)
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Volume 22 (2016)
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Volume 21 (2015)
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Volume 20 (2014)
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Volume 19 (2013)
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Volume 18 (2012)
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Volume 17 (2011)
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Volume 16 (2010)
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Volume 15 (2009)
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Volume 14 (2008)
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Volume 13 (2007)
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Volume 12 (2006)
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Volume 11 (2005)
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Volume 10 (2004)
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Volume 9 (2003)
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Volume 8 (2002)
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Volume 7 (2001)
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Volume 6 (2000)
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