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2000
Volume 11, Issue 10
  • ISSN: 1381-6128
  • E-ISSN: 1873-4286

Abstract

Spinal cord trauma activates the immune system and elicits leukocyte recruitment to the site of injury. This increase in immunological activity contributes to acute lesion expansion over a period of days to weeks following the initial trauma. At the same time, inflammatory cells and mediators facilitate endogenous repair processes such as axonal sprouting and remyelination. Thus, to be effective, therapies that target the immune system must limit the destructive effects of neutrophil, macrophage and lymphocyte activation, while simultaneously preserving their reparative functions.

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/content/journals/cpd/10.2174/1381612053507468
2005-04-01
2025-05-13
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  • Article Type:
    Review Article
Keyword(s): immunology; inflammation; neuroprotection; pathology; spinal cord injury
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