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Volume 2, Issue 1
  • ISSN: 2666-7797
  • E-ISSN: 2666-7800

Abstract

Background

Orange coloured tubular calyx of can be utilized as a substitute for saffron due to the presence of crocin, an apocarotenoid, which can act as a sunscreen agent. Petroselinic acid is reported to have a moisturizing effect on the skin.

Objective

To utilize the tubular calyx of Nyctanthes arbor- tristis as an economical source of crocin and seed oil as a source of petroselinic acid for the development of a stable phytosomal gel formulation and to evaluate its sunscreen and moisturizing activities.

Methodology

Phytosomes of standardized crocin-rich extract and petroselinic acid were prepared separately by lipid film hydration technique. The phytosomes were then incorporated into a gel base prepared from dehydroxanthan gum, and it was evaluated for sunscreen activity by using Mansur’s equation. Moisturizing effect of the phytosomal gel was evaluated on 10 healthy female volunteers with their informed consent, and the water content of the stratum corneum was measured by using a Digital Moisture detector pen before and 5 hours later the application of the gel.

Results

Mean initial moisture content of the skin was found to be 30.08%, which was significantly ( < 0.05) raised to 45.59% at the end of 5 hours. Sun Protection Factor was found to be 15.09 and with a Boot Star rating of 2.

Conclusion

Entrapping the phytoconstituents in vesicles increased stability, and the formulation was found to have moderate protection and a good moisturizing effect on the skin.

© 2023 Bentham Science Publishers
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2023-06-22
2025-01-01

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/content/journals/cosci/10.2174/2666779702666230403111920
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Formulation Containing Phytosomes of Crocin-Rich Extract from Nyctanthes arbor-tristis and Petroselinic Acid from Coriandrum sativum seeds Exhibits Sunscreen and Moisturizing Effects
Curr. Cosm. Sci. 2, E030423215414 (2023); https://doi.org/10.2174/2666779702666230403111920
/content/journals/cosci/10.2174/2666779702666230403111920
/content/journals/cosci/10.2174/2666779702666230403111920
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  • Article Type:     Research Article
Keyword(s): Coriandrum sativum; Crocin; moisturizing; Nyctanthes arbor-tristis; petroselinic acid; sunscreen

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