Current Organic Synthesis - Volume 21, Issue 1, 2024

Aim: Organic Electro-optic (EO) materials have recently gained considerable attention owing to their advantages compared to inorganic EO materials. Among different kinds of organic EO materials, organic EO molecular glass exhibits desired prospect because of its high chromophore loading density and large macroscopic EO activity. Introduction: The objective of this study is to design and synthesize a novel organic E Read More

1, 2, 3-triazoles display enormous applications in the extensive fields of chemistry such as pharmaceuticals, ligands, conjectures, etc. Among these classes of compounds, the Nunsubstituted triazole emerges as a potent applicant for various fields of chemistry and therefore synthetic procedures for this molecular scaffold possess certain importance. Moreover, from an environmental perspective, metal-free organic synthesis gain Read More

The development of an active, selective, and long-term selective catalyst for the synthesis of biologically active heterocycles is still challenging. However, magnetic nanocatalysts have divergent applications like high efficiency, selectivity, consumption, and reusability. The current review explores a detailed survey of the latest information on synthetic methods of Pyrano [3, 2-c] chromene derivatives using different magne Read More

Background: Downy mildew is one of the major fungi causing significant economic losses to crops. The resistance of this fungus to current fungicides is increasing and new fungicides with a unique mode of action are needed. Objective: To find a novel pyrazole amide derivative as a potential fungicide. Methods: A series of pyrazole-5-carboxamide derivatives containing a diaryl ether were designed and synthesized by Read More

Introduction: L-proline is an efficient chiral small-molecule organocatalyst for the direct asymmetric aldol reaction between unmodified acetone and a variety of aldehydes. Methods: However, it is difficult to separate from the reaction medium for reuse. In this work, polyacrylic acid (PAA) supported The acylation reaction between L-hydroxyproline and PAA prepared lproline (P(AA-co-PA)) catalysts with various catalyst loadi Read More

Introduction: Seven new psoralen derivatives were synthesised by carbodiimide coupling to active carboxylic acid to amide formation in mild reaction conditions. Methods: The psoralen derivatives were produced through the condensation of seven different types of amine groups consisting of electron withdrawing groups and electron donating groups. Results: All the synthesised compounds were obtained with mo Read More

Background: Hydrated strontium perchlorate [Sr(ClO4)2.3H2O] acts as a very strong oxidizing and dehydrating agent. Until now, it could not be reported as a catalyst in dehydration mechanism-based organic synthetic reactions. Therefore, it is important to find whether it could be an effective catalyst for one-pot multicomponent reactions (MCRs). Objective: The main objective of the present work is the development o Read More

The present application describes a class of compounds exhibiting a coronavirus 3CL protease inhibitory effect and pharmaceutically acceptable salts thereof, and a pharmaceutical composition containing the same. The application also provides the synthesis of compounds and efficacy from in vitro and cell- based assays.