Current Organic Synthesis - Volume 21, Issue 6, 2024

> Background: Porphyrins are highly conjugated heterocyclic compounds and are found as the backbone of many natural products such as heme and chlorophyll. To improve its biological and optical properties, the functionalization of porphyrin at its β- and meso-position has gained importance in recent years. Objective: The purpose of this review is to describe the Pictet-Spengler method for the incorporation of nitrogenous and Read More

The thiazole derivatives as important members of heterocyclic compounds have attracted much synthetic interest due to their different biological properties. In recent years, studies on the synthesis of morpholine compounds have increased because of the properties of this core. In particular, the hybrid structures in which the thiazole ring is linked to morpholine nuclei in one molecular frame have gained popularity. The present Read More

Transition metals catalyzed C-H bond activation reactions have appeared as an emerging field to introduce different functional groups in the inactivated saturated and unsaturated C-H bonds. C-S and C-Se bond constructions in aromatic scaffolds are very interesting due to the important applications of organochalcogen reagents in pharmaceutical chemistry and the material world. The introduction of sulphur or selenium Read More

>Background: Three imine derivatives (1, 2 & 3) have been prepared via condensation reaction of phenyl hydrazine, 2-hydrazino pyridine and 4-methoxy aniline with 4-formyl pyridine. Materials and Methods: Electron impact mass spectrometry (EIMS), proton nuclear magnetic resonance (1H-NMR), ultra violet- visible (UV-Vis) and fourier transform infrared (FTIR) spectroscopy have been utilized for the characterization. Th Read More

>Background: The emergence of drug-resistant bacteria and multidrug-resistant diseases, both of which are associated with high mortality, has posed a serious global health issue. Thiazoles and coumarins were reported as antimicrobial agents. Objective: This research paper aims to describe the synthesis of some novel thiazole derivatives bearing a coumarin residue as antibacterial agents. Methods: The thiazole - co Read More