Current Organic Synthesis - Volume 11, Issue 4, 2014

Development of efficient routes to many kinds of fused heterocycles is an attractive area of research since these compounds constitute one of the most interesting divisions of organic chemistry. A majority of the compounds produced by nature as well as significant numbers of compounds synthesized in the industrial sector each year have heterocyclic rings as part of their structures. This survey research works on the speci Read More

Solid acid catalysts are the best alternative to existing homogeneous protic acids, being less toxic, easy to handle and most importantly having the additional possibility to be reused several times. In recent years, silica has been employed as porous support to immobilize a series of acid species towards the design of novel solid acid catalysts. These materials have been employed in several organic reactions, including alkylation, a Read More

Tuberculosis (TB), mainly caused by Mycobacterium tuberculosis, is the leading killer among all infectious diseases worldwide and is responsible for more than two million deaths annually. The recent increase in the number of multi-drug resistant clinical isolates of M. tuberculosis has created an urgent need for the discovery and development of new antituberculosis leads. This review covers recent reports terpenoids that have d Read More

Microwave-Assisted Organic Synthesis (MAOS) is one of the most current trends in organic chemistry. Herein, both the most popular and new approaches in microwave-syntheses of very important linkage in Nature - amide bond - are overviewed and compared with conventional synthetic routes.

We prepared a series of bis-indole derivatives from different aldehydes and/or substituted isatins using molecular iodine as a catalyst and propylene carbonate as a “green” solvent. Simply stirring the components at room temperature produced high yield compound synthesis with a methodology that is clean, economical and efficient.

We describe the synthesis and characterization of three compounds targeting the enzyme 17β-hydroxysteroid dehydrogenase type 1. The first one is a 4-aminobenzoyl-phenylacetic acid derivative designed as a mimic of adenosine-phosphate, the second one is an estradiol derivative having a decyl side chain at position 16β, and the third one is a hybrid compound with the adenosine-phosphate mimic covalently linked to the C1 Read More

Buchwald-Hartwig coupling reaction was employed to furnish new class of substituted piperazine-fused thio-quinolinyl Schiff bases. Synthesis of thiocarbonyl quinoline moiety was attempted using Lawesson’s reagent followed by esterification achieved using ethyl bromoacetate in refluxing acetone. Substantial C-N coupling of various piperazine or piperidine bases to the C-6 position of quinoline ring system was accomplishe Read More