A Sustainable Approach to Bis-Indole Synthesis Using Propylene Carbonate as an Eco-Friendly Solvent

We prepared a series of bis-indole derivatives from different aldehydes and/or substituted isatins using molecular iodine as a catalyst and propylene carbonate as a “green” solvent. Simply stirring the components at room temperature produced high yield compound synthesis with a methodology that is clean, economical and efficient.