Current Organic Synthesis - Volume 11, Issue 2, 2014

This review covers the functionalization of 4,7-dihydroindole derivatives as synthetic equivalents (synthons) for 2-substituted indoles.

Iminosugars continue receiving a great deal of attention from chemists and biochemists for their potential as pharmaceutics. This is a comprehensive review of the methods found in the literature for the synthesis of piperidine, pyrrolidine, indolizidine, and pirrolizidine iminosugars, starting from D/L-erythrose and D/L-threose carbon chains (tetroses). This review shows the crescent popularity of small molecules to b Read More

Enantioselective epoxidation of olefins is a useful synthetic route in organic synthesis, as a wide variety of olefins is available and optically active epoxides can be converted into various functionalities with high regio- and stereoselectivity. Chiral manganese(III)- salen catalyst, which is commonly known as the Jacobson-Katsuki catalyst, has been reported as selective and efficient catalyst for the epoxidation of unfunctio Read More

γ-Hydroxybutenolides are readily available reagents that are useful starting materials for the synthesis of simple and complex compounds. This review will discuss the role tautomerism plays in the reactivity profile of γ-hydroxybutenolides, the major modes of reactivity of γ-hydroxybutenolides, and the application of this methodology for the synthesis of biologically important molecules.

Marine natural products are recognized as a fruitful source of drug development due to their rare structural entities and diverse biological activities, and consequently, publicized number of metabolites as new medicines. Although extensive progress has been made in identifying novel bioactive molecules from marine source, endeavors to explore these molecules for medicinal applications are much needed. Marine fun Read More

Hydrophilization of Polyamide 46 (PA46) via modification with acetaldehyde in continuous phase was studied. The chemical modification of PA 46 with acetaldehyde resulted in a water-swollen polymer with hydrophilic property. The polyamide 46 undergoes a nucleophilic addition with acetaldehyde in the presence of aluminum chloride as a catalyst. The extent of bulk hydroxyethylation using AlCl3 resulted in 95.65% m Read More

A series of sulfides was successfully synthesized by a thiol-disulfide exchange reaction using disulfides as the reactive substance. After cleavage of S-S bonds by ammonium thioglycolate catalysis, Michael addition reactions were performed using various acceptors in one-pot. The catalyzed-reaction mechanism has been discussed based on the by-products. In addition, 2,3H-1,5- benzothiazepines were also successfully synth Read More

BINOL-based diphosphite ligands containing oxygen or nitrogen heteroatoms are currently a new class of promising ligands for homogeneous catalysis. Herein we present a useful strategy to synthesize ditopic (R)-BINOL-based diphosphites, containing pyridyl or propyl ether bridges between BINOL fragments in high isolated yields (50-92 %). Their rhodium complexes were evaluated in styrene hydroformylation, in wh Read More

Pyrrolidine was used as a catalyst for the simple, convenient, and highly efficient synthesis of dihydropyrano[2,3-c]pyrazole derivatives. Four-component one-pot reactions of β-ketoester, hydrazine, ethyl glyoxalate or ethyl pyruvate, and malononitrile in ethanol under reflux conditions led to excellent yields of 79%-94%.