Current Organocatalysis - Volume 4, Issue 2, 2017

Background: Since 1960s, vitamin B1 has been used as a catalyst in biochemical process and serves as a coenzyme for important types of transformations. The term “organocatalyst” is a concatenation of the words “organic” and “catalyst.” Vitamin B1 is an organocatalysis and structure of vitamin B1 contains a pyrimidine ring and a thiazole ring linked by a methylene bridge. Vitamin B1 is a nonflammable, water Read More

Peptides play crucial roles in the nature and execute almost all biochemical transformations in the form of proteins, enzymes, hormones, neurotransmitters and/or toxins. Just to mimic the effective properties of enzyme in bio-catalysis, we have to gain knowledge in structure of synthetic peptides and their role mainly in catalysis. Application of oligopeptides as catalysts in order to mimic the performance of enzy Read More

Urea and its derivatives, which are usually generated through the carbonylation reaction between amines and carbonylation reagent, have been found widespread applications in agriculture and pharmaceuticals. Among the carbonylation reaction, it is the most appealing and promising strategy that employs CO2 as a green carbonylation reagent. However, CO2 inherent thermodynamic stability and kinetic inertness limit Read More

Background: Due to significant biological activity associated with N-, O- and Sheterocycles, a number of reports for their synthesis have appeared in recent decades. Traditional approaches require expensive or highly specialized equipment or would be of limited use to the synthetic organic chemist due to their highly inconvenient approaches. This review summarizes the applications of gold catalysts with emphasis of their sy Read More

Background: L-proline as a famous and most applied organocatalyst contains a nucleophilic secondary amino group and a carboxylic acid moiety functioning as a Brønsted acid has been used to catalyze more and more essential transformations. Although the L-proline is commercially available at low cost, however the organocatalytic methods in general require high catalyst loading for the achievement of high conversi Read More