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Volume 11, Issue 4
  • ISSN: 2213-3372
  • E-ISSN: 2213-3380

Abstract

Background

Knoevenagel condensation is an important C-C bond formation reaction catalyzed by various homogeneous and heterogeneous acid-base catalysts.

Methods

The present work describes the eco-friendly preparation of magnetic nanoparticles FeO (MNPs) and its functionalization to FeO@SiO@SOH. The prepared MNPs and their functionalized materials were fully characterized by FT-IR, XRD, FE-SEM, HR-TEM, and VSM. Further demonstrated application of these catalysts for the C-C bond formation reactions of Knoevenagel condensation employing special aldehyde derivatives with malononitrile at room temperature gave excellent product isolation.

Results

The application of the prepared functionalized MNPs for the Knoevenagel condensation was demonstrated by the reaction of various aryl/heterocyclic and cholesterol aldehyde with malononitrile at room temperature stirring for about 30 min in ethanol solvent. The final product isolated is confirmed by various spectroscopic techniques such as FT-IR, 1H-, & 13C-NMR, and mass spectrometry. Furthermore, the selected compounds are screened for their photophysical properties, and interestingly compound showed good fluorescent properties.

Conclusion

Overall the present work described a greener method preparation of MNPs, and its functionalized employed as a heterogeneous catalyst for the Knoevenagel condensation of various aryl/heterocyclic and cholesterol aldehyde with malononitrile. The method developed is simple, easily separated catalyst by an external magnet, and recycled up to five cycles without any noticeable change in the final product isolation. Further, the prepared derivatives screened for their photophysical properties, and interestingly compound showed good fluorescent properties.

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2024-12-01
2024-11-26

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Green Method Synthesis of Magnetic Nanoparticles and its Functionalized MNPs for Knoevenagel Condensation Reaction
Curr. Organocatal. 11, 330 (2024); https://doi.org/10.2174/0122133372292087240228082859
/content/journals/cocat/10.2174/0122133372292087240228082859
/content/journals/cocat/10.2174/0122133372292087240228082859
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  • Article Type:     Research Article
Keyword(s): agro-waste; eco-friendly; fluorescence; heterogeneous catalysis; Knoevenagel reaction; magnetic nanoparticles

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