Current Organocatalysis - Volume 2, Issue 1, 2015

1, 3-butadiynes, also known as the conjugated diynes, are important structures with rigid full-carbon sketch, and they have been found to exist widely in nature from the marine organisms to the interstellar space. Besides the special physiological activities, diynes have also been found to be crucial in material science. This review will focus on the synthesis of diynes, and more importantly, their existence and bioactivities, as w Read More

Dearomatization strategies of heteroaromatic compounds such as benzofurans, indoles, thiophenes, pyridines, and other heteroaromatic compounds afford the most efficient protocol for the synthesis of highly bioactive molecules, natural products and commercially available drugs. The use of these strategies has been significantly increased, which has fascinated several research groups as the dearomatization strat Read More

The catalytic influence of inorganic salts, polarity of solvent and addition of chosen additivities on free radical reactions of tin hydrides has been reviewed. There have been collected examples of different reactions as hydrostannation of alkynes with mixed tin hydrides as well as enantioselective reductions of derivatives of 2-bromo-2-arylpropionates, α-iodocoumarin and acetophenone with tin hydrides. For all of t Read More

Diversity oriented synthetic protocol has been presented for the synthesis of structurally diverse drug -like small molecules. The present method involves three-component domino reaction of 2- aminobenzothiazoles, thiophene-2-carbaldehyde and carbonyl compounds in the presence of a catalytic amount of p-toluenesulphonic acid (p-TSA) as a recyclable and reusable eco-friendly acid catalyst in aqueous- alcoholic mediu Read More

L-Arginine catalyzed Knoevenagel condensation of active methylene compounds, 2-cyano-N-(2- nitrophenyl)acetamide, 2-cyanomethyl benzimidazole, ethylcyanoacetate with benzaldehydes, indole-3- carboxaldehydes under mild and efficient conditions resulting in the formation of respective products. The isolation procedure is quiet easy and products recovered without further purification.

Acid treatment of montmorillonite enhanced the acidity and also nanoporosity of the virgin clay. Montmorillonite clay was treated with p-TSA and HCl under microwave irradiation (MWI) and modified materials were characterized by BET, TPD-NH3 and FT-IR techniques. The activities of clays were studied for important condensation reactions such as the crossed aldol condensation and amide synthesis without solvent under M Read More

A series of new chiral bifunctional Ferrocenylphosphines was designed, synthesized and applied for the asymmetric aza-Morita-Baylis-Hillman reaction of N-sulfonated imines with methyl vinyl ketone (MVK). The reaction proceeded under mild conditions to afford the desired aza-MBH adducts in moderate to high yields with up to 56% ee value.

A soluble glutathione peroxidase mimic with the optimum structure (NCD-Te-NCD2.2) was constructed based on the supramolecular host-guest interaction. The self-assembled structure and catalytic mechanism of NCD-Te-NCD2.2 were detailed investigation. It was proved that NCD-Te-NCD2.2 could form the hollow vesicle-like aggregates in water. And saturation kinetics measurement indicated that NCD-Te- NCD2.2 exhi Read More

Glucosamine as a kind of important nature chiral scaffold is widely regarded for its obvious advantages such as cheap, stable and readily available. In this communication, we reported the introduction of L-proline group at the amino functional group of D-glucosamine resulted in several efficient prolinamide organocatalysts, which could efficiently catalyze the asymmetric aldol reaction between acetone and various substituted be Read More