Current Organocatalysis - Volume 10, Issue 4, 2023

Background: In the search for a new and effective synthetic approach to biologically chromene-derived compounds, a series of 2-amino-7, 7-dimethyl-5-oxo-4Htetrahydrochromene- 3-carbonitrile derivatives (4a-i) were synthesized. This synthesis involved the use of 4-(dimethylamino)pyridiniump-toluenesulfonate (DPTS) as a catalyst in an aqueous medium. Additionally, the relative stability between iso Read More

Aim: The synthesis of diverse N-substituted pyrroles utilizing rice malt is identified. The reaction of hexane-2,5-dione with various primary amines develops the intriguing pyrrole scaffold in moderate to good yields. Methods: The reaction was carried out at room to ambient temperature in an extremely environmentally benign condition, without the need for any additional solvents or catalysts. Results: In the synthesis of N-deriv Read More

Background: Globally, type 2 diabetes mellitus (T2DM) prevalence is increasing. A patient must have lifetime therapy for diabetes to manage it and prevent any complications. There are many different medications that can be used to treat Type 2 diabetes. Still, almost all of them concentrate on the declining insulin sensitivity and secretion that are associated with the onset of the illness. Methods: There is growing interest in the d Read More

Introduction: We synthesized proline functionalized ionic liquid and further characterized it with analytical techniques. Method: After getting proper structural information on the above ionic liquid, we utilized them as a catalyst for the asymmetric Mannich-Type Reaction. Result: We synthesized 6 different types of β-amino α-cyano sulfones derivatives as Mannich adduct using various combinations of different imines and aryl sulph Read More

Background: Determination of diagnostically significant components of biological materials using enzyme-free microscopic sensors is an urgent scientific task, which is being worked on by a significant number of scientific groups in the world. This is due to the fact that microscopic sensor-active tracks on inert surfaces can be obtained without preliminary manufacturing of precision templates. Methods: Laser Induced Che Read More

Background: Catalysis has been widely applied in pharmaceutical companies in recent years. This paper reports a useful new approach for the synthesis of pyranopyrazoles. Objectives: One- pot synthesis of pyranopyrazoles using MgZrO 3@Fe 2O 3@ZnO as a novelcore- shell nanocatalyst which increases reaction rate, selectivity, ease of work-up and recyclability of the supports. Method: The present study deals with the sy Read More

Introduction: In this article, succinimidinium perchlorate as a new acidic ionic liquid catalyst was prepared and used to synthesize 5-arylidene barbituric acid and pyrano[2,3- d]pyrimidinone derivatives. Method: These two derivatives of barbituric acid have a variety of useful properties. Result: The advantages of this reagent were high yields, high efficiency, short reaction times, easy performance, easy work-up and reus Read More