Current Organocatalysis - Volume 10, Issue 1, 2023

Background: In this study, a heterogeneous catalyst containing MIL-101(Cr) functionalized TEDA-BAIL was used to carry out an efficient four-component reaction between aromatic aldehydes, barbituric acid, dimedone, and aryl amines, resulting in the synthesis of a new class of pyrimido[4,5-b]quinolinetrione derivatives. Methods: Pyrimido[4,5-b]quinolinetrione derivatives were synthesized through a one-pot four Read More

Background: The synthesis of 2-azapyrrolizidine scaffolds has fascinated scientists due to their potential biological activities. Objective: An efficient and environmentally sustainable synthetic method has been presented to synthesize structurally various 2-azapyrrolizidines via a three-component reaction. Methods: The condensation of aldehydes, hydantoin, and malononitrile in the presence of green and sustainable sulfamic acid Read More

The synthesis of Proline-2-triethyl-ethylamide hexafluorophosphate (ILPA-PF6) (with 96% yield) and further the application during the synthesis of (R)-9-Methyl-5(10)-octaline-1,6-dione (Wieland-Miescher ketone molecule) are defined in this manuscript. The suggested protocol signifies one of the most efficient methods for the synthesis of these flexible chiral building blocks in good yield. The evident solubility of ionic liquids allo Read More

Background: Several types of catalysts have been cited in the literature. However, the current work showed that a multi-component reaction involving aldehydes, malononitrile, and resorcinol or α/β-naphthol could produce 2-amino-4H-chromene in a more environmentally friendly manner. The reaction is optimized by both stirring and microwave methods, but the reaction carried out under microwave irradiation is found to Read More

Background: Ketone is one of the important functional groups in synthetic chemistry. For this reason, organic chemists focused on the synthesis of ketone starting from various functionalities since nineties. One of the method deals with the conversion of carboxylic acids to ketones in a one pot manner. We have recently reported a one pot transformation of carboxylic acid to ketone using TsCl or MsCl as an activator of carboxylc Read More

Background: An efficient and green strategy for the synthesis of 2-arylbenzoxazoles using [Bmim]PF6 ionic liquid as a catalyst has been investigated via the condensation of oaminophenol with aldehydes. The microwave-assisted synthesis features some advantages such as good yield of products, broad substrate scope, short reaction time, and absence of metal catalyst and solvent. Furthermore, the synthesis could be convenientl Read More