Skip to content
2000
Volume 3, Issue 2
  • ISSN: 2213-3372
  • E-ISSN: 2213-3380

Abstract

A simple, straightforward and eco-friendly protocol for the synthesis of pharmaceuticallyinteresting aryl/heteroaryl-substituted bis(6-aminouracil-5-yl)methane derivatives has been developed using sulfamic acid (NH2SO3H) as a cost-effective and non-toxic organo-catalyst via pseudomulticomponent reaction of 6-amino-1,3-dimethyluracil with aromatic/heteroaromatic aldehydes in aqueous ethanol at room temperature. Mild reaction conditions, good to excellent yields, ecofriendliness, easy isolation of products and avoidance of column chromatographic separation are some of the notable features of this protocol.

Loading

Article metrics loading...

/content/journals/cocat/10.2174/2213337202666150812231130
2016-05-01
2025-06-24
Loading full text...

Full text loading...

/content/journals/cocat/10.2174/2213337202666150812231130
Loading
This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error
Please enter a valid_number test