Current Organocatalysis - Volume 3, Issue 2, 2016

Organocatalytic reactions are now becoming powerful tools in the construction of simple to complex molecular skeletons and this field is growing rapidly with new concepts and designs. During the recent past, sulfamic acid (NH2SO3H) has emerged as an efficient organocatalyst in the formation of both carbon-carbon and carbon-heteroatom bonds, thereby resulting different classes of organic compounds of potential i Read More

A simple, straightforward and eco-friendly protocol for the synthesis of pharmaceuticallyinteresting aryl/heteroaryl-substituted bis(6-aminouracil-5-yl)methane derivatives has been developed using sulfamic acid (NH2SO3H) as a cost-effective and non-toxic organo-catalyst via pseudomulticomponent reaction of 6-amino-1,3-dimethyluracil with aromatic/heteroaromatic aldehydes in aqueous ethanol at room te Read More

Considerable number of nitrogen containing active pharmaceutical ingredients and natural products are frequently synthesized from optically pure β-amino ketones, aldehydes, esters, and alcohols. Synthesis of 1,3-amino ketones, aldehydes, alcohols and esters engages Mannich-type reactions, the most important basic reaction-types in organic chemistry. The current trend in the development of asymmetric Mannich-type reacti Read More

Cellulose nanoribbons obtained from bacterial fermentation have been esterified by means of a solventless organocatalytic route. The esterification methodology involves acetic anhydride as acylant and three different α-hydroxy acids were tested as organocatalysts. By tuning the acetylation interval, bacterial nanocellulose (BNC) with varying degree of substitution could be obtained (i.e. DS=0.27-0.90). Esterified B Read More

An efficient, simple and environmentally benign methodology has been developed for the synthesis of 5,6-unsubstituted 1,4-dihydropyridine derivatives by a three-component condensation of β-keto esters, amines and α,β-unsaturated aldehydes under solvent-free conditions catalyzed by an aprotic imidazole-based zwitterionic salt. The key advantages of this protocol are metal-free reaction conditions, short reaction time, Read More

The multicomponent reactions involving the use of environmentally benign solvents, and non-toxic, and recyclable organocatalysts require special attention as with such significant characters, the multicomponent reactions satisfy the green chemistry’s principles to a greater extent. The environmentally benign synthetic protocols with the amalgamation of multicomponent reactions, characterized by synthetic efficiency a Read More

This is the first report on the organocatalytic activity of simple unsubstituted p-tertbutylcalix[ 8]arene, C8 towards multi-ring heterocycles. We thereby account an expeditious, ecofriendly, high throughput procedure of the synthesis of some biologically active cores xanthenes and acridines along with spiro-derivatives of both with the aid of the organocatalyst C8. The catalyst is recyclable for at least six cycles without substa Read More

A DBU-catalyzed one-pot multicomponent reaction involving indane-1,3-dione, aldehydes, and 1,4-dithiane-2,5-diol for the synthesis of spirocyclic tetrahydrothiophene derivatives has been developed. A series of spirocyclic tetrahydrothiophene derivatives were obtained in generally good to excellent yields with high diastereoselectivity via this synthetic strategy. Importantly, this methodology has several advantages, such as Read More