A Novel Synthesis and Quantitation Route of Belinostat

This research article describes the production, quantification, and purification of Belinostat from 3-nitrobenzaldehyde as the starting material. A cascade-step process produces higher yields when compared to all previous existing methodologies.

The procedure involved the following: Horner–Wadsworth–Emmons (HWE) reaction of aromatic aldehydes with triethylphosphonoacetate in the presence of potassium carbonate, reduction of the nitro group to the amino group, sulfochlorination by thionyl chloride, aniline-mediated sulfonamidation, and hydroxylamine amidation as the last step.

The prepared solid Belinostat was purified, and an acceptable yield of 56-60% was obtained.

The approach has several key benefits, including low-cost beginning materials, straightforward techniques, safer and more reliable results, and substantial environmental advantages.