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Volume 12, Issue 1
  • ISSN: 2213-3372
  • E-ISSN: 2213-3380

Abstract

The overuse and improper disposal of antibiotics may add to the continuous rise of antimicrobial resistance (AMR). In this work, we demonstrate a sequential effect of two novel catalytic systems consisting of MIL-100(Fe) MOF (Metal Organic Framework) and MnO nanosheets to degrade amoxicillin antibiotic through the destruction of β lactam group.

Methods

The catalysts were fabricated chemical method. the catalysts exhibit large surface area, excellent porosity, excellent catalytic activity, and insolubility and can be easily separable from the reaction mixture.

Results

The sequential use of MIL-100(Fe) MOF and MnO nanosheets could showcase 92% degradation of amoxicillin within 1.5 hours under ambient conditions without any significant residual bi-product as confirmed by LCMS studies.

Conclusion

Impressively, the antimicrobial susceptibility of degraded residue is lessened by 33% as compared to pure amoxicillin.

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2024-10-07
2025-07-04

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/content/journals/cocat/10.2174/0122133372327833240924104209
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Can the Mineralization of Antibiotics from Water Bodies be a Significant Step in the Fight Against Alarming Antimicrobial Resistance?
Curr. Organocatal. 12, 58 (2025); https://doi.org/10.2174/0122133372327833240924104209
/content/journals/cocat/10.2174/0122133372327833240924104209
/content/journals/cocat/10.2174/0122133372327833240924104209
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  • Article Type:     Research Article
Keyword(s): amoxicillin; Antimicrobial resistance; catalytic degradation; MIL-100(Fe) MOF; MnO2 nanosheets; water bodies; β lactam degradation

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