Current Organic Chemistry - Online First

Porphyrins and their analogues, due to their unique physicochemical properties, have a wide range of applications. Synthetic tetraarylporphyrins with an asymmetric substituent system are of particular interest. In this regard, an asymmetric porphyrin was synthesized, containing a phenyl fragment on the periphery of the porphyrin macrocycle. Subsequent quaternization of the compound with methyl iodide was carried out Read More

Heterocyclic rings containing heteroatoms at the 1,4-position and fused to a benzene ring are essential in medicinal chemistry due to their wide range of therapeutic and biological properties. Among them, 1,4-benzoxazine derivatives are distinguished by their heterocyclic structure, characterized by the fusion of a benzene ring with an oxazine ring with oxygen and nitrogen atoms in 1,4-positions. The latter heterocycl Read More

Naturally occurring coumarin compounds with the typical benzopyrone framework are found in remarkable concentrations in plants. Moreover, they have also been found in animals, microbes, and other sources. The versatility of the coumarin scaffold extends beyond medicinal chemistry, with applications in agrochemistry, cosmetics, and fragrances. However, this review focuses on the diverse biological activities of metal- Read More

Terpenes and terpenoids, which are a large and diverse class of organic compounds, are widely distributed in many plants. In recent years, there has been a growing interest in the biosynthesis and biological activity of terpenes and terpenoids in order to fully exploit their efficacy in a wider range of applications, such as medicine, biology, flavors and fragrances, food, and cosmetics. This review aims to update and elucidate Read More

In this study, a series of 2-amino-4-(substituted phenyl)-5,6,7,8-tetrahydroquinoline -3-carbonitrile derivatives (IVa-j) was synthesized using a one-pot process. The titled compounds were successfully synthesized by employing aromatic aldehydes with satisfactory yields. Docking studies were directed to explore the DNA-binding interactions of the synthesized compounds. These studies involved docking the compounds with B-D Read More

Heterocyclic scaffolds, particularly indole and thiazole compounds, are revolutionizing the treatment of lung diseases due to their structural diversity and broad therapeutic potential. Their ability to target multiple biological pathways positions them as powerful tools for developing innovative treatments for lung disorders, particularly lung cancer. This review systematically explores recent advances in the synthesis a Read More

This review examines the reactivity of bis(α-cyanoacetamides) attached to various spacers in producing heterocyclic and macrocyclic molecules. Bis(α-cyanoacetamides) contain two electrophilic and three nucleophilic sites, allowing for multiple coupling reactions. They are regarded as potent chemical reagents capable of producing various heterocyclic derivatives with potential biological applications. The current review covers Read More

This review investigates the reactivity of cycloheptane-based β-ketoesters in producing α-functionalized derivatives. Cyclic β-ketoesters are a versatile chemical reagent that can react with suitable electrophiles to produce a variety of α-functionalized derivatives with excellent synthetic potential and promising biological properties. This review covers all reports on α-functionalization of cycloheptane-based β-ketoesters, in Read More