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Volume 29, Issue 6
  • ISSN: 1385-2728
  • E-ISSN: 1875-5348

Abstract

This review summarizes the recent trends in the transition-metal-catalyzed C-H bond functionalization approach to access -branched (hetero)aryl/alkenyl/alkyl glycosides with reaction characteristics and proposed mechanisms. Recently, the transition-metal-catalyzed C-H functionalization has arisen as a groundbreaking and versatile method for producing potent -branched glycosides feasibly and efficiently. Nowadays, site-selective functionalization of C-H bonds in carbohydrate chemistry is highly demanded, owing to the intricate and highly stable nature of C-H bonds. In this context, we systematically summarize the C-H glycosylation of arenes, C-H arylation of glycoside, and Cattelani-strategy with mechanistic investigation. Also, the applications of transition-metal-catalyzed -glycosylation for the formation of biologically active molecules are discussed.

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2024-08-29
2025-03-14

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/content/journals/coc/10.2174/0113852728326485240815110646
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Emerging Advances in Transition Metal-catalyzed C-H Bond Functionalizations Towards C-glycosides
Current Organic Chemistry 29, 423 (2025); https://doi.org/10.2174/0113852728326485240815110646
/content/journals/coc/10.2174/0113852728326485240815110646
/content/journals/coc/10.2174/0113852728326485240815110646
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  • Article Type:     Review Article
Keyword(s): C-glycosides; C-H functionalization; carbohydrate; glycosylation; transition metals; transition-metal catalysis

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