Current Organic Chemistry - Volume 17, Issue 2, 2013

In the last years, there are more and more reports published in prestigious journals addressing the successful application of essential oils for the eradication or prevention of microbial biofilms. Moreover, by combining the unique properties of nanoparticles with the antimicrobial activity of the essential oils, functionalized surfaces with an improved resistance to microbial colonization and biofilm development were obtained. The Read More

Staphylococcus (S.) aureus is a versatile human pathogen responsible for both nosocomial and community acquired infections. The ability of this opportunistic pathogen to cause a large spectrum of infections is due to an impressive spectrum of virulence determinants. The coordinated expression of many virulence determinants during the infectious process is regulated by the agr quorum-sensing system (QS). Different Read More

Nano-sized silver powders coated with sodium oleate (NanoAg@C18) was prepared by a simple wet chemical route and characterized by FT-IR, DTA-TG, TEM, SAED and EDS. The main objective of this research was to successfully employ the NanoAg@C18 for the inhibition of bacterial and fungal biofilms in vitro development on catheter sections with a film-coated surface. The lower value of the relative microbial biomass f Read More

New dibenzo[b,e]thiepins were synthesized, characterized by elemental analysis, spectral studies (1H-NMR, 13C-NMR, IR) and screened for their microbicidal and antibiofilm properties. The new dibenzo[b,e]thiepins and their sulfones exhibited a broad spectrum of antimicrobial activity (superior for the S-oxidized compounds) being effective at low concentrations against a wide range of infectious microorganisms. The o Read More

The aims of this research were to obtain improved wound dressings based on collagen (COLL), polysaccharides (dextran= DEX, diethylaminoethyl-cellulose= DEAEC), silica network and usnic acid, as quorum sensing inhibitor. FT-IR, SEM, interaction with eukaryotic cells and a novel protocol to evaluate the antimicrobial activity of the new wound dressing, firstly reported in literature were used for the characterization of fabricat Read More

Interaction of the single-stranded DNA (ssDNA) aptamers and proteins was investigated on graphene oxide (GO)-based biosensors. GO was applied for biological applications because of its unique properties, which include water dispensability, exclusive selection of ssDNA, and fluorescence-quenching effects. In this study, aptamer-functionalized GO sheets of nanometer-scale thickness and micrometer-scale dimension were Read More

The purpose of this study was to investigate how a viral infection affecting the epithelial cells could be influenced by the presence of the opportunistic Staphylococcus aureus soluble mediators. The viral antigens presence, apoptosis and cytokine profiles of HeLa cells infected with HSV-1 and pre-/postreated with different bacterial soluble fractions were evaluated. Soluble bacterial molecules could modulate HeLa ce Read More

Control orientation and interparticle spacing of self-assembled nanoparticles can provide versatile functional materials for optical and electronic applications. In this study, we have obtained a glass substratum with tunable optical properties using flowing control and bimolecular competition. The surface of glass was modified from immobilized stretchable gold nanoparticle chains. The long and periodic single-stranded DNA na Read More

Bacteria commonly communicate with each other by a cell-to-cell signaling mechanism known as quorum sensing, using soluble mediators. Recent studies showed that these molecules target not only bacteria, but also interact with the eukaryotic host. Pseudomonas aeruginosa infection occurs both in acute or chronic states in a variety of respiratory and urinary infections. These infections are often difficult to treat, and numero Read More

During the last years significant efforts have been made to discover compounds with inhibitory activity of quorum-sensing systems, which could represent an anti-pathogenic strategy, since they will inhibit the coordinated expression of virulence determinants, without interfering with bacterial growth, being less likely to generate resistance. The present study is reviewing the main types of quorum sensing inhibitors known to dat Read More

The aim of this paper is to review the antimicrobial activity of thiourea derivatives against planktonic and adherent bacterial and fungal strains, as well as to show how nanotechnology could improve the intrinsic antimicrobial activity of the novel substances, by obtaining biocompatible nanocomposites based on magnetite nanoparticles and newly synthesized 2-((4-ethylphenoxy)methyl)-N- (alkylphenylcarbamothioyl) be Read More

Three new potent CO2-philic propane derivatives were designed and synthesized. Their structures were characterized by NMR, FTIR, and elemental analysis. Phase behavior of the three compounds was investigated at temperatures ranging from 313 K to 333 K and pressures from 9.1 MPa to 16.1 MPa in supercritical carbon dioxide, the solubility differences were discussed. The experimental solubility data were calculated and Read More

Present work is dedicated to studies of kinetic regularities of α-ethylacrolein and crotonaldehyde oxidation in methanol, allyl alcohol and glycidol. Kinetic model of the reaction has been designed based on experimental data. Rate constants of hydrogen peroxide disappearance and rate constants of unsaturated acid and its ester formation for both aldehydes in different alcohols at various catalyst concentrations and tem Read More

Novel pyrazoles, bipyrazoles and pyrazol-3-ylpyrazolo[3,4-d]pyrimidines were synthesized using the versatil synthon 2-(1Hbenzimidazol- 2-yl)-3,3-bis(methylthio) acrylonitrile (1). Reactions were carried out under silent and ultrasonic conditions. In general, improvement in rates and yields were observed when reactions were carried out under ultrasonic irradiation compared with silent condition. Structures of the products were e Read More