Current Organic Chemistry - Volume 17, Issue 11, 2013

Cancer is the principal cause of death in economically developed countries and the second leading cause of death in developing countries, and this disease is very rapidly growing as a result of both population aging and adoption of cancer-associated routine choices including smoking, physical sedentariness, and ‘‘westernized’’ nourishments. Thus, there is an increasing demand on anticancer drugs, and this demand must be fo Read More

According to the Green Chemistry principles, water is the first choice solvent to reduce chemical waste and environmental impact of chemical industry. Reaction in water can be improved when microwave irradiation is applied to a synthetic procedure due to the possibility to reach temperatures higher than the boiling point. This is especially true when reactions are carried out in superheated/ subcritical conditions ( Read More

Research concerning green solvents is focused on reducing environmental damages due to the use of toxic solvents in organic chemistry. Hence, there have been developed a lot of solvent-free processes as well as more efficient recycling protocols in the last decades. Unfortunately, these approaches have their limitations. Therefore, the authors review different environmentally benign solvent alternatives. This report highli Read More

The use of biocatalysis for the provision of optically active building blocks and other useful compounds for fine chemicals and pharmaceutical industries is nowadays a mature technology. To further improve the ecological footprints of these applications, there is currently an increasing interest in using biomass-derived solvents for enzyme-catalyzed processes that may be implemented at industrial level on a midterm ba Read More

Chemistry and pharmacological activity of various types of Mannich bases and their derivatives were well documented. A survey of the literature revealed extensive studies on the synthesis and reactivity of Mannich bases derived from ketones, amides, enamines, phenols and indoles of widely different structures, while comparatively little attention has been given to Mannich bases derived from nitroalkanes and related nitroco Read More

This paper gives an overview of the available methods for racemization of amines and related derivatives, and the racemization catalysts can be coupled with enzymes to achieve the dynamic kinetic resolution, which provides enantiopure products with approximate 100% yields. Transition metal-catalyzed racemization, free radical-based racemization, racemase leading to automatic racemization and alkali-catalyzed racem Read More