Current Organic Chemistry - Volume 10, Issue 12, 2006

It is a real pleasure for me to serve as the executive guest editor for Current Organic Chemistry's special issue on recent developments in the synthesis of heterocycles by transition-metal catalyzed cyclization reactions. The importance of heterocycles in many field of Science (including Organic Chemistry, Inorganic Chemistry, Bioorganic Chemistry, Biological Chemistry, Agricultural Chemistry, Industrial Chemistry, Phar Read More

This review concerns the preparation of heteropolycyclic systems in a single operation using palladium complexes and is restricted to methods where the palladium intervenes in at least two sequential different transformations.

The design and development of highly efficient catalytic methods for the synthesis of carbocycles and heterocycles has been the subject of extensive study, because of their relevance to life sciences and material sciences. Among various available synthetic methods, the transition-metal-catalyzed cyclization reactions has attracted much attention for the transformation of simple starting materials into heterocyclic scaffol Read More

In most cases where ring closing metathesis is applied to the synthesis of heterocycles, α,ω-dienes are used as precursors. If substrates containing more than two double bonds are subjected to a metathesis reaction, carba- or heterocycles bearing additional exocyclic alkene functionality result, or multiple ring closing processes occur. This offers interesting and potentially very useful synthetic perspectives. On the other hand, sel Read More

The synthesis of heterocyclic compounds such as lactones, lactams, pyrrolidinones and others can be achieved by cyclocarbonylation reactions catalyzed by transition metal complexes. The combination of palladium salts with certain different ligands turned out to be the most efficient catalyst systems to accomplish such cyclocarbonylation reactions. New synthetic strategies and novel approaches devoted to the prepar Read More

In the past decades, the great potential of palladium catalysis has been widely used in the de novo construction of the functionalized benzo[b]furan ring and in the selective functionalization of the preformed benzo[b]furan system providing a broad range of new and versatile procedures. The de novo construction of the benzo[b]furan system generally involves the assembly of the furan nucleus on a benzenoid scaffold via intramo Read More

This review summarizes the recent developments in transition metal-catalyzed 1,n-enyne cyclization reactions that have been reported in the literature from January 1, 2002 to April 30, 2005. The cyclizations described herein include four parts according the reaction mechanism, i. e. cyclization initiated by oxidative cyclometallation; by activation of the triple bond to form a vinyl metal species; by electrophilic activatio Read More

The application of reductive carbonylation of nitroarenes to the synthesis of fine chemicals is described. The review focuses on the results reported from 1996 onwards and is mainly divided in two parts, respectively describing the intra-molecular cyclization reactions of nitroarenes bearing in the ortho position a suitable functional group and the intermolecular reactions of nitroarenes with external olefins and alkynes. Benzo-fused Read More