Current Organic Chemistry - Volume 10, Issue 14, 2006

The progress achieved both in the solid and liquid phase of the synthetic methodologies for peptides, permitted the application of various chemistries for preparing totally synthetic proteins and protein-like macromolecules of branched architecture. Polypeptides with molecular masses in the 10-25 kDa range have been successfully prepared using either the step by step and fragment condensation or the chemoselectiv Read More

Thiooligosaccharides display inhibitory activity against glycoside hydrolases and they constitute a valuable tool for structural biology. The construction of the interglycosidic linkage, in which the oxygen atom is replaced by sulfur, usually involves one of the following reactions: i) nucleophilic displacement of good leaving groups in a carbohydrate moiety by a sugar thiol, ii) Michael and Michael-type additions of sug Read More

Degenerative joint diseases (e.g. rheumatoid arthritis or osteoarthritis) represent a major cause of disability and early retirements in the industrialised countries. These diseases affect primarily the cartilage of the larger joints and destroy its macromolecular constituents. Cartilage covers the ends of the bones acting as a weight bearing, low friction, wear resistant tissue. It is known that the composition of cartilage i Read More

The fixation of ligands onto molecules, surfaces and materials by use of reactions using a simple and unified chemistry is among the everlasting desires of chemists. Besides the general insensitivity with respect to the chemical structures of the ligand, the completeness of the reaction as well as the insensitivity from external reaction parameters (i.e.: solvents, ambient temperature) is wished. The copper(I)-catalysed azide/alky Read More

The lithiation electrophilic substitution sequence of aromatic compounds has become very a common methodology for ortho-introduction of a long list of substituents in general. In particular, it was centered around the orthosubstitution of aromatic carboxylic acids via their masked forms. Till now, long list of reviews concerning tertiary amides or oxazolines as directing groups has been referred. On the other hand, secondary Read More

The stereoselective formation of chiral tertiary alcohols is of great importance for the synthesis of enantiomerically pure natural products and pharmaceuticals. The simplest approach for the preparation of chiral alcohols is the enantioselective addition of organometallic reagents to carbonyl compounds. Hundreds of catalysts promote nucleophilic additions of organometallic compounds to aldehydes with high enantio Read More