Current Organic Chemistry - Volume 10, Issue 6, 2006

Welcome to the fifth special issue of Current Organic Chemistry devoted to carbohydrate chemistry.1-5 As we witness unprecedented growth and interest in the subject, from the introduction of glycobiology through the molecular recognition of carbohydrates, and their supramolecular chemistry, the idea to continue to cover these diversified topics is one of the great temptations. The aim is to present authorative overvi Read More

As the structural constituents of many naturally occurring molecules, synthesis of functionalized carbocyclic derivatives has been widely investigated. Among numerous approaches to construct carbocyclic compounds, there is an efficient way of forming carbocyclic derivatives by the use of various monosaccharides as chiral building blocks. In this review, synthetic conversions to functionalized carbocyclic compounds f Read More

Receptors with the sugar unit incorporated into the macrocyclic structure - their synthesis and complexing abilities - are reviewed. The receptors with the disaccharide moieties (although such derivatives are rare) including sucrose are also described in this review.

Because of the number of distinguishable interactions within the DNA major groove, there is considerable interest in discovering the governing factors involved in DNA recognition. Carbohydrates represent a class of DNAinteractive agents capable of binding the major groove due to their size and intricate distribution of hydrophobic and hydrophilic interactions within their molecular structure. To date a limited number of ca Read More

The recent discovery of RNA interference (RNAi) as an efficient and naturally occurring mechanism of gene regulation has revitalized interest in chemically modified RNA analogues. For potential in vivo applications, either in preclinical settings or as therapeutic agents, small interfering RNAs (siRNAs) will require chemical modifications to finetune the thermal stability and increase potency, cellular uptake, and in vivo half-life of Read More