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Volume 15, Issue 1
  • ISSN: 2468-1873
  • E-ISSN: 2468-1881

Abstract

Introduction

The major goal of this work is to develop letrozole nanoparticles using the polymer precipitation technique. Formulations were prepared by using Ethyl cellulose and Eudragit S100 as polymers.

Methods

By varying drug-polymer ratios, a total of ten formulations were prepared. By altering the drug concentration to polymer, five formulations were prepared with Ethyl cellulose and five with Eudragit S100. All ten formulations were evaluated for different characterization and evaluation parameters such as Entrapment efficiency, Loading capacity and drug release studies, particle size, stability (zeta potential), surface morphology, and drug-polymer interaction study.

Result

In comparison, the NEC 2:1 formulation showed the smallest particle size, high stability, good entrapment efficiency, and sustained drug release. This formulation was further studied to determine the anticancer activity in the MCF-7 Breast cancer cell line by MTT assay. The results indicated that the prepared formulation exhibited anticancer activity with an IC50 value of 91.26 micromolar.

Conclusion

Comparatively, Ethyl cellulose was proven to be a better polymer than Eudragit S100, and the nanoprecipitation technique was considered the most suitable technique for preparing letrozole nanoparticles.

© 2025 Bentham Science Publishers
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/content/journals/cnanom/10.2174/0124681873283442240228054238
2024-03-18
2024-12-25

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/content/journals/cnanom/10.2174/0124681873283442240228054238
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Formulation of Letrozole-loaded Ethyl Cellulose and Eudragit S100 Nanoparticles by Nanoprecipitation Technique and Determination of Cytotoxic Activity by MTT Assay
Curr Nanomed 15, 95 (2025); https://doi.org/10.2174/0124681873283442240228054238
/content/journals/cnanom/10.2174/0124681873283442240228054238
/content/journals/cnanom/10.2174/0124681873283442240228054238
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  • Article Type:     Research Article
Keyword(s): Letrozole; MTT assay, ethyl cellulose; nanoparticles; nanoprecipitation; solvent evaporation

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