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Current Molecular Pharmacology - Online First
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7
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Upregulation of miR-3130-5p Enhances Hepatocellular Carcinoma Growth by Suppressing Ferredoxin 1: miR-3130-5p Enhances HCC Growth via Inhibiting FDX1
Authors: Wanwen Xu, Shengbo Liao, Ying Hu, Yinghui Huang and Jie ZhouAvailable online: 17 March 2025More LessBackground: Hepatocellular carcinoma [HCC] is a leading cause of cancer-related mortality worldwide, necessitating the exploration of novel therapeutic targets. Although accumulating studies have identified Ferredoxin 1 [FDX1], a key regulator of cuproptosis, as a candidate tumor suppressor and potential therapeutic target, its role and mechanism remain elusive in HCC. Methods: The FDX1 expression was investig Read More
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The Mitochondrial Targeting Drug SkQ1 Attenuates the Progression of Post-Traumatic Osteoarthritis through Suppression of Mitochondrial Oxidative Stress
Authors: Zhen-Ya Zhi and Peng-Cheng WangAvailable online: 17 March 2025More LessBackground Post-traumatic osteoarthritis (PTOA) constitutes a distinct subtype of osteoarthritis (OA). Despite extensive research, no effective pharmacological intervention has been established to prevent or halt the progression of PTOA. Current therapeutic approaches are primarily limited to symptomatic management and pain relief. SkQ1, a novel mitochondria-targeted antioxidant, has emerged as a promising ther Read More
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Exploring the Immune-Related Molecular Mechanisms Underlying the Comorbidity of Temporal Lobe Epilepsy and Major Depressive Disorder through Integrated Data Set Analysis
Authors: Shi Yan, Zhibin Han, Tianyu Wang, Aowen Wang, Feng Liu, Shengkun Yu, Lin Xu, Hong Shen, Li Liu, Zhiguo Lin and Meng NaAvailable online: 18 February 2025More LessBackground:Temporal lobe epilepsy (TLE) and major depressive disorder (MDD) are prevalent and complex neurological disorders that affect individuals globally. Clinical and epidemiological studies indicate a significant comorbidity between TLE and MDD; however, the shared molecular mechanisms underlying this relationship remain unclear. This study aims to explore the common key genes associated with TLE and MD Read More
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Two GnRH-mitoxantrone Conjugates, Con-3 and Con-7, Target Endometrial Cancer Cells
Available online: 03 February 2025More LessIntroduction: Endometrial cancer is one of the most common gynecological malignancies. Endometrial cancer cells express the gonadotropin-releasing hormone (GnRH) and its receptor (GnRH-R). Among the various therapeutic approaches for the treatment of endometrial cancer is the use of GnRH conjugates, such as the AN-152, created by linking the [D-Lys6] GnRH with the cytotoxic doxorubicin through an ester bond. Read More
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The Involvement of the NEAT1-1/miR-873-5p/GalNAcT-I Axis in the Development of Neuroblastoma
Authors: Zhigang Hu, Huiming Wang, Juan Wang, Yanbin Fang, Chi Sun, Xiaofeng Yang and Weili XuAvailable online: 27 January 2025More LessBackground: The most prevalent extracranial solid tumor in childhood is neuroblastoma (NB), which arises from undifferentiated neural crest cells. However, the prognosis of this condition remains unfavorable, and the underlying mechanisms of its origin are still elusive. Therefore, this study aimed to investigate the specific mechanism underlying NEAT1-1 in NB. Methods: In this study, the expressions of NEAT1-1, miR-873-5p, Read More
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Thymol and Carvacrol as Potential Tocolytic and Anti-inflammatory Agents in Pregnant Rat Uterus
Available online: 09 January 2025More LessIntroduction: This work aimed to evaluate the anti-inflammatory and myorelaxant effect of thymol (TM) and carvacrol (CAR) in the pregnant rat uterus. Both compounds exhibit considerable antimicrobial, antispasmodic, and anti-inflammatory effects and due to these properties, they were studied in this in vitro model of premature birth induced by infection. Method: All uterine tissues were studied in uterine contraction tests Read More
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Chrysin: A Potential Antiandrogen Ligand to Mutated Androgen Receptors in Prostate Cancer
Available online: 09 January 2025More LessBackground: Androgen receptor mutations, particularly T877A and W741L, promote prostate cancer (PCa). The main therapies against PCa use androgen receptor (AR) antagonists, including Bicalutamide; but these drugs lose their effectiveness over time. Chrysin is a flavonoid with several biological activities, including antitumoral properties; however, its potential as an antiandrogen must be explored. Objective: The presen Read More
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