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- Volume 8, Issue 4, 2012
Current Medical Imaging - Volume 8, Issue 4, 2012
Volume 8, Issue 4, 2012
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Clinical Impacts in Cardiovascular Molecular Imaging: the Example of Cardiac Sympathetic Imaging in Heart Failure
More LessWith the current advances in genomics and proteomics, cardiovascular molecular imaging techniques such as PET and SPECT, in combination with other cardiac molecular imaging techniques, will identify new markers of disease activity and will play a central role in screening of patients, diagnosis, prognosis and patient management. The complexity of the development process of vulnerable atherosclerotic plaques provid Read More
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Image-Guided Photonic Energy Deposition for Cancer Ablation and Drug Delivery
By Chun LiNovel nanoparticles, including various gold nanostructures with intrinsic optical properties can be tuned to have strong absorption in the near-infrared region. These nanoparticles have been shown to be useful for a variety of potential applications in biomedicine, including cancer molecular imaging, photothermal ablation therapy, and controlled drug delivery. In this article, we provide an up-to-date review of these nanoparti Read More
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In Vivo Neuronal Cell Differentiation Imaging From Transplanted Stem Cells
By Dong Soo LeeIn vivo cell tracking has been enabled by molecular imaging technology and, recently, monitoring cell fate changes has become possible in small animals. Stem cells and induced pluripotent stem cells (iPSCs) can differentiate in vivo after implantation, and lineage commitment of these cells can be successfully imaged using cell-specific promoterdriven reporter genes. For this purpose, imaging sensitivity has been significantly Read More
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Clinical Application of PET Myocardial Perfusion Imaging
Authors: Zhi Jiang, Jianan Wang and Hong ZhangCoronary artery disease is the major cause of death in developed countries. PET myocardial perfusion image has become more important in the diagnosis and risk stratification for coronary artery disease patients. The available evidence supported that PET is the “gold standard” for detecting myocardial perfusion, comparing to other noninvasive assessment techniques. Its ability to quantify absolute myocardial blood flow and Read More
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Progress on Multi-Modality Molecular Imaging
More LessMolecular imaging technologies have undergone explosive growth during the past two decades, providing noninvasive and quantitative imaging of biological and biochemical processes within intact living subject. Conventional anatomical imaging techniques such as X-ray computed tomography (XCT) or magnetic resonance imaging (MRI) can offer detailed anatomical structures but are weak in providing physiological information Read More
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Radiolabelled Quinoline Derivaties for the PET Imaging of Peripheral Benzodiazepine Receptor
Authors: Ming Lei, Wan Tian, Zu-Jin Zhan and Hong ZhangPeripheral benzodiazepine receptor (PBR) has been implicated in the regulation of various cellular processes, including regulation of steroidogenesis,immunomodulation, porphyrin transport, heme synthesis, cell apoptosis and proliferation. Also, PBR expression levels were shown to be increased in a variety of cancers indicating its important role in cancer development.The investigation and biological evaluation of Read More
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Structural Biology Toward Rational Drug Development in Collaboration with Molecular Imaging
Authors: Takashi Umehara, Mikako Shirouzu and Shigeyuki YokoyamaOne of the most costly steps in drug development is the identification of a genuinely druggable compound for human beings, from pre-clinical animal model research. In order to overcome this problem, the importance of screening compounds with desirable distributions and metabolism in human bodies, using a microdosing technique, is increasingly apparent. In addition, screening compounds with high ligand efficiency is c Read More
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Functional Neuroimaging of Stimulation by Music Using Positron Emission Tomography
Authors: Ying Zhang, Mei Tian and Hong ZhangMusic is one of the oldest experimental study subjects in psychology. Functional neurological techniques, including functional magnetic resonance imaging (MRI), positron emission tomography (PET), electroencephalography and magnetoencephalography, are powerful methods of investigation of neural structure and functional correlates of music processing in humans. Herein, we offer a conceptual review of music and method Read More
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Validation in Medical Image Processing: Methodological Issues for Proper Quantification of Uncertainties
More LessValidation is now considered as a mandatory step in any development of new medical image processing methods, systems, or components. It allows studying performances and adequacy with clinical applications, and comparison with similar solutions. Being able to correctly answer these three issues requires proper design, performance, and report of validation studies and results. This could be made easier by 1) the use Read More
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Update Clinical Application of Diffusion Tensor Imaging
Authors: Shan Jiang, Weihua Liu and Meiyun ZhangDiffusion tensor imaging (DTI) is an effective technology for the study of the internal structure of the brain non-invasively. At present, this technology is widely applied to clinical diagnosis and can reflect a series of pathological changes in the microstructure due to changes in nerve fibers. This article first explains the basic principles of DTI and some parameters like fractional anisotropy (FA) and relative anisotropy (R Read More
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Volumes & issues
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Volume 21 (2025)
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Volume 20 (2024)
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Volume 19 (2023)
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Volume 18 (2022)
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Volume 17 (2021)
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Volume 16 (2020)
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Volume 15 (2019)
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Volume 14 (2018)
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Volume 13 (2017)
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Volume 12 (2016)
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Volume 11 (2015)
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Volume 10 (2014)
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Volume 9 (2013)
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Volume 8 (2012)
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Volume 7 (2011)
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Volume 6 (2010)
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Volume 5 (2009)
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Volume 4 (2008)
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Volume 3 (2007)
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Volume 2 (2006)
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Volume 1 (2005)
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