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Volume 20, Issue 1
  • ISSN: 1573-4056
  • E-ISSN: 1875-6603
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Abstract

Objective

To analyze the efficacy of microwave ablation (MWA) guided by computed tomography (CT) and 1.5T magnetic resonance (MR) in the treatment of VX2 para-vascular liver tumor model in rabbits.

Materials and Methods

Sixty para-vascular VX2 liver tumor models in rabbits were randomly divided into CT-guided microwave ablation group (CT group, n=35) and MR-guided microwave ablation group (MR group, n=35). The complete ablation rate, mean operation time, postoperative complication rate and mean survival time were compared between the two groups.

Results

In the CT group, the rate of complete ablation was 68.6% (24/35), and the mean operation time was 42.1 ± 9.7 minutes. Three cases had ascites and one case had abdominal wall injury. In the MR group, the rate of complete ablation was 94.2% (33/35), and the mean operation time was 53.4 ± 10.9 minutes. One case was complicated with ascites. No serious complications such as pneumothorax, liver abscess, pleural effusion and diaphragm perforation were found in both groups. Between the two groups, the difference in complete ablation rate was statistically significant (P=0.006 < 0.05). A statistically significant difference can also be found in mean operation time (P < 0.01). The follow-up time was 21 days after the operation. As for the postoperative complication rate (11.4% in the CT group and 2.9% in the MR group, P=0.353) and mean survival time (16.9 ± 1.8 days in CT group, 18.3 ± 2.3 days in the MR group, P=0.925), the differences were not statistically significant.

Conclusion

Compared with CT guidance, although the microwave ablation time under MR guidance was longer, the complete ablation rate under MR guidance was high, which proved that MR guidance was a more effective way of microwave ablation guidance and was worth promoting in the clinic. In this experiment, the postoperative complication rate was lower in the MR group, although the difference was not statistically significant, which may be related to the small sample size, and the subsequent study on the postoperative complication rate can increase the sample content.

© 2024 The Author(s). Published by Bentham Science Publisher.
This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: https://creativecommons.org/licenses/by/4.0/legalcode. This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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2024-01-01
2024-10-15

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References

  1. CaoW. ChenH.D. YuY.W. LiN. ChenW.Q. Changing profiles of cancer burden worldwide and in China: A secondary analysis of the global cancer statistics 2020.Chin. Med. J.2021134778379110.1097/CM9.000000000000147433734139
     [Google Scholar]
  2. JiaoH.B. WangW. GuoM.N. SuY.L. PangD.Q. WangB.L. ShiJ. WuJ.H. Evaluation of high-risk factors and the diagnostic value of alpha-fetoprotein in the stratification of primary liver cancer.World J. Clin. Cases202210269264927510.12998/wjcc.v10.i26.926436159417
     [Google Scholar]
  3. VillanuevaA. Hepatocellular Carcinoma.N. Engl. J. Med.2019380151450146210.1056/NEJMra171326330970190
     [Google Scholar]
  4. JinT. LiuX. ZhangH. CaoY. DaiC. TangS. XuF. Ultrasound-guided percutaneous microwave ablation for hepatocellular carcinoma adjacent to large vessels: a propensity score matching analysis.Int. J. Hyperthermia202037195596410.1080/02656736.2020.180407632781862
     [Google Scholar]
  5. ZhaoH.T. CaiJ.Q. Chinese expert consensus on neoadjuvant and conversion therapies for hepatocellular carcinoma.World J. Gastroenterol.202127478069808010.3748/wjg.v27.i47.806935068855
     [Google Scholar]
  6. SuwaK. SekiT. AoiK. YamashinaM. MurataM. YamashikiN. NishioA. ShimataniM. NaganumaM. Efficacy of microwave ablation versus radiofrequency ablation for hepatocellular carcinoma: A propensity score analysis.Abdom. Radiol.20214683790379710.1007/s00261‑021‑03008‑933675382
     [Google Scholar]
  7. YiH. CaiB. AiX. LiK. SongP. ZhangW. Early identification of residual tumors following microwave ablation using contrast-enhanced ultrasonography in a rabbit VX2 liver cancer model.BioMed Res. Int.202020201910.1155/2020/246205833029496
     [Google Scholar]
  8. PochF.G. GeyerB. GemeinhardtO. KlopfleischR. NiehuesS.M. VahldiekJ.L. BressemK. KreisM.E. LehmannK.S. Immediate post-interventional contrast-enhanced computed tomography overestimates hepatic microwave ablation – an in vivo animal study.Int. J. Hyperthermia202037146346910.1080/02656736.2020.176293632396401
     [Google Scholar]
  9. KeS. Advances in the interventional therapy of hepatocellular carcinoma originating from the caudate lobe.J. Interv. Med.202252515610.1016/j.jimed.2022.03.00235936660
     [Google Scholar]
  10. TsangS.H. MaK.W. SheW.H. ChuF. LauV. LamS.W. CheungT.T. LoC.M. High-intensity focused ultrasound ablation of liver tumors in difficult locations.Int. J. Hyperthermia2021382566410.1080/02656736.2021.193321734420450
     [Google Scholar]
  11. MukundA. RamalingamR. AnandparaK.M. PatidarY. VijayaraghavanR. SarinS.K. Efficacy and safety of percutaneous microwave ablation for hepatocellular carcinomas <4 cm in difficult location.Br. J. Radiol.20209311162019102510.1259/bjr.2019102532970472
     [Google Scholar]
  12. FengX DasSK FengGL Efficacy and safety of MRI and CT Guided VX2 hepatic para-vascular tumor model in rabbits.Curr. Med. Imaging.202219111302130710.2174/1573405618666220929094804
     [Google Scholar]
  13. EisenhauerE.A. TherasseP. BogaertsJ. SchwartzL.H. SargentD. FordR. DanceyJ. ArbuckS. GwytherS. MooneyM. RubinsteinL. ShankarL. DoddL. KaplanR. LacombeD. VerweijJ. New response evaluation criteria in solid tumours: Revised RECIST guideline (version 1.1).Eur. J. Cancer200945222824710.1016/j.ejca.2008.10.02619097774
     [Google Scholar]
  14. MulierS. NiY. JamartJ. RuersT. MarchalG. MichelL. Local recurrence after hepatic radiofrequency coagulation: Multivariate meta-analysis and review of contributing factors.Ann. Surg.2005242215817110.1097/01.sla.0000171032.99149.fe16041205
     [Google Scholar]
  15. ShinS.W. AhnK.S. KimS.W. KimT.S. KimY.H. KangK.J. Liver resection versus local ablation therapies for hepatocellular carcinoma within the milan criteria.Ann. Surg.2021273465666610.1097/SLA.000000000000435033074898
     [Google Scholar]
  16. HanY ZhiWH FanSP YanD XuF Risk factors of residual tumor in single small hepatocellular carcinoma after thermal ablation treatment.Zhonghua. Nei. Ke. Za. Zhi.202261554354710.3760/cma.j.cn112138‑20211004‑00675
     [Google Scholar]
  17. CalandriM. GazzeraC. YevichS. LapennaK. MarencoM. VeltriA. ParaluppiG. FonioP. Post-surgical recurrence of hepatocellular carcinoma along resection margin treated by percutaneous US-guided ablation.Minerva Surg.201873325526010.23736/S0026‑4733.18.07643‑529471619
     [Google Scholar]
  18. YuZ. LiG. YuanN. DingW. Comparison of ultrasound guided versus CT guided radiofrequency ablation on liver function, serum PIVKA-II, AFP levels and recurrence in patients with primary hepatocellular carcinoma.Am. J. Transl. Res.20211366881688834306439
     [Google Scholar]
  19. LiangJ ZhangS HanZ LiY SunH KimY KimT. Comparative study of application of computed tomography/ultrasound and computed tomography imaging guidance methods in the microwave ablation of liver cancer.J. Comput. Assist. Tomogr.2023471243010.1097/RCT.0000000000001375
     [Google Scholar]
  20. WeissJ. HoffmannR. RemppH. KeβlerD.E. PereiraP.L. NikolaouK. ClasenS. Feasibility, efficacy, and safety of percutaneous MR-guided ablation of small (≤12 mm) hepatic malignancies.J. Magn. Reson. Imaging201949237438110.1002/jmri.2625230221797
     [Google Scholar]
  21. LiZ. WangC. SiG. ZhouX. LiY. LiJ. JiaoD. HanX. Image-guided microwave ablation of hepatocellular carcinoma (≤5.0 cm): Is MR guidance more effective than CT guidance?BMC Cancer202121136610.1186/s12885‑021‑08099‑733827464
     [Google Scholar]
  22. LiC. ZhangK. LiuM. XuY. HeX. SequeirosR.B. Multiparametric magnetic resonance-guided and monitored microwave ablation in liver cancer.J. Cancer Res. Ther.20201671625163310.4103/jcrt.JCRT_1024_2033565509
     [Google Scholar]
  23. WinkelmannM.T. GohlaG. KüblerJ. WeißJ. ClasenS. NikolaouK. HoffmannR. MR-guided high-power microwave ablation in hepatic malignancies: Initial results in clinical routine.Cardiovasc. Intervent. Radiol.202043111631163810.1007/s00270‑020‑02584‑532699978
     [Google Scholar]
  24. XuK. LiZ. LiuY. LiuZ. WangC. JiaoD. HanX. 2450-MHz microwave ablation of liver metastases under 3.0 T wide-bore magnetic resonance guidance: A pilot study.Sci. Rep.20221211264010.1038/s41598‑022‑16989‑435879411
     [Google Scholar]
  25. WangYM QianGJ XuY Efficacy of microwave ablation in treatment of hepatocellular carcinoma within the Milan criteria: A report of 696 cases.Zhonghua. Gan. Zang. Bing. Za. Zhi.201725534434810.3760/cma.j.issn.1007‑3418.2017.05.007
     [Google Scholar]
  26. LiZ. WangC. LiJ. LiuZ. JiaoD. HanX. MR-guided microwave ablation of hepatocellular carcinoma (HCC): Is general anesthesia more effective than local anesthesia?BMC Cancer202121156210.1186/s12885‑021‑08298‑234001036
     [Google Scholar]
  27. WeissJ. HoffmannR. ClasenS. MR-guided liver interventions.Top. Magn. Reson. Imaging201827316317010.1097/RMR.000000000000014629870468
     [Google Scholar]
/content/journals/cmir/10.2174/1573405620666230908111713
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Comparative Study of CT and MR Guided Microwave Ablation in the Treatment of Para-vascular VX2 Liver Tumor Model in Rabbits
Curr. Med. Imaging 20, E080923220823 (2024); https://doi.org/10.2174/1573405620666230908111713
/content/journals/cmir/10.2174/1573405620666230908111713
/content/journals/cmir/10.2174/1573405620666230908111713
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  • Article Type: Research Article
Keyword(s): Computed tomography; Liver Tumor model; Magnetic resonance imaging; Microwave ablation; Rabbit VX2 tumor; Therapeutic effect

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