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Volume 20, Issue 1
  • ISSN: 1573-4056
  • E-ISSN: 1875-6603
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Abstract

Background

Dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) is considered a promising method in lung lesion assessment.

Methods

Sixty-four patients with single pulmonary lesions (SPLs) received DCE-MRI at 3.0 T. Of them, 49 cases were diagnosed with lung cancer, and 15 with benign pulmonary nodules (8 inflammatory nodules, 5 tuberculosis, and 2 abscesses). SPLs were quantitatively analyzed to determine the pulmonary lesions-related perfusion parameters, including reflux constant (Kep), volume transfer constant (K), the maximum slope of increase (MaxSlope), extravascular extracellular space volume fraction (Ve), apparent diffusion coefficient (ADC), the initial area in the signal intensity-time curve (IAUGC), and contrast-enhancement ratio (CER). In addition, a Student’s t-test was conducted to calculate statistical significance regarding the quantitatively analyzed perfusion parameters in benign SPLs compared to malignant SPLs. The area under (AUC) the receiver operating characteristic (ROC) curve was studied to investigate the performance of perfusion parameters in diagnosing lung cancer.

Results

Values of K, Kep, Ve, MaxSlope, and IAUGC increased within malignant nodules relative to benign nodules (K: 0.21 ±0.08 . 0.73 ±0.40, P = 0.0001; Kep: 1.21 ±0.66 . 1.83 ±0.90, P = 0.0163; Ve: 0.24 ±0.08 . 0.47 ±0.18, P < 0.0001; MaxSlope: 0.09 ±0.14 . 0.28 ±0.29, P = 0.0166; IAUGC: 0.18 ±0.09 . 0.55 ±0.34, P = 0.0001). Meanwhile, malignant nodules presented higher ADC than benign nodules (0.0016 ±0.0006 . 0.0012 ±0.0003, P = 0.0019). K and IAUGC showed the best diagnostic performance with AUCs [1.0, 95%CI (0.99–1.0); 0.93, 95%CI(0.85–1.0), respectively].

Conclusion

Malignant pulmonary lesions had higher values of Ktrans, Ve, Kep, MaxSlope, and IAUGC compared to benign pulmonary lesions. Overall, perfusion parameters of DCE-MRI facilitate discrimination between benign from malignant pulmonary nodules.

© 2024 The Author(s). Published by Bentham Open.
© 2024 The Author(s). Published by Bentham Open. This is an open access article published under CC BY 4.0 https://creativecommons.org/licenses/by/4.0/legalcode
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2024-01-01
2024-11-22

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Discrimination between Benign and Malignant Lung Lesions using Volumetric Quantitative Dynamic Contrast-enhanced MRI
Curr. Med. Imaging 20, E270723219206 (2024); https://doi.org/10.2174/1573405620666230727111222
/content/journals/cmir/10.2174/1573405620666230727111222
/content/journals/cmir/10.2174/1573405620666230727111222
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  • Article Type:     Research Article
Keyword(s): ADC; AUC; Diagnosis; Dynamic contrast-enhanced magnetic resonance imaging; Lung lesions; Single pulmonary lesion (SPL)

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