Skip to content
2000
  1. Home
  2. A-Z Publications
  3. Current Medical Imaging
  4. Volume 20, Issue 1
  5. Article
Volume 20, Issue 1
  • ISSN: 1573-4056
  • E-ISSN: 1875-6603
file format pdf download PDF
side by side viewer icon HTML

Abstract

Background

Alterations in ocular blood flow play an important role in the pathogenesis of diabetic macular edema; however, this remains unclear.

Objectives

This study aimed to investigate ocular blood flow in eyes with or without diabetic macular edema using arterial spin labeling.

Methods

This cross-sectional study included 118 eyes of 65 patients with diabetic retinopathy analyzed between November 2018 and December 2019. We included a total of 53 eyes without diabetic macular edema (mean [SD] age, 57.83 [7.23] years; 29 men [54.7%]) and 65 eyes with diabetic macular edema (mean [SD] age, 60.11 [7.63] years; 38 men [58.5%]). Using a 3.0-T magnetic resonance imaging, participants were imaged with arterial spin labeling with multiple post-labeling delays.

Results

The mean ocular blood flow at post-labeling delays of 1.5 and 2.5 s was significantly lower in eyes with diabetic macular edema among patients with diabetic retinopathy compared with the remaining subgroups (P=0.022 and P <0.001, respectively). The mean ocular blood flow exhibited a significant decrease in eyes with diabetic macular edema when the post-labeling delay was set at 2.5 s in the nonproliferative and proliferative diabetic retinopathy groups, compared with the remaining subgroups (P=0.005 and P=0.002, respectively). The cutoff points of ocular blood flow at post-labeling delays of 1.5 s and 2.5 s were 9.40 and 11.10 mL/100 g/min, respectively.

Conclusion

Three-dimensional pseudocontinuous arterial spin labeling can identify differences in the ocular blood flow of patients with diabetic eyes with and without diabetic macular edema.

© 2024 The Author(s). Published by Bentham Science Publisher.
This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: https://creativecommons.org/licenses/by/4.0/legalcode. This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Loading

Article metrics loading...

/content/journals/cmir/10.2174/0115734056307305240403060707
2024-04-30
2025-06-22

  • From This Site

    /content/journals/cmir/10.2174/0115734056307305240403060707
    dcterms_title,dcterms_subject,pub_keyword
    -contentType:Contributor -contentType:Concept -contentType:Institution
    10
    5
The full text of this item is not currently available.

References

  1. KleinR. KleinB.E.K. MossS.E. CruickshanksK.J. The wisconsin epidemiologic study of diabetic retinopathy. xv. the long-term incidence of macular edema.Ophthalmology1995102171610.1016/S0161‑6420(95)31052‑47831044
     [Google Scholar]
  2. LechnerJ. MedinaR.J. LoisN. StittA.W. Advances in cell therapies using stem cells/progenitors as a novel approach for neurovascular repair of the diabetic retina.Stem Cell Res. Ther.202213138810.1186/s13287‑022‑03073‑x35907890
     [Google Scholar]
  3. LeeB. NovaisE.A. WaheedN.K. AdhiM. de CarloT.E. ColeE.D. MoultE.M. ChoiW. LaneM. BaumalC.R. DukerJ.S. FujimotoJ.G. En face Doppler optical coherence tomography measurement of total retinal blood flow in diabetic retinopathy and diabetic macular edema.JAMA Ophthalmol.2017135324425110.1001/jamaophthalmol.2016.577428196198
     [Google Scholar]
  4. WesselM.M. NairN. AakerG.D. EhrlichJ.R. D’AmicoD.J. KissS. Peripheral retinal ischaemia, as evaluated by ultra-widefield fluorescein angiography, is associated with diabetic macular oedema.Br. J. Ophthalmol.201296569469810.1136/bjophthalmol‑2011‑30077422423055
     [Google Scholar]
  5. VaghefiE. PontréB. Application of arterial spin labelling in the assessment of ocular tissues.BioMed Res. Int.2016201611310.1155/2016/624050427066501
     [Google Scholar]
  6. KhanalS. TurnbullP.R.K. VaghefiE. PhillipsJ.R. Repeatability of arterial spin labeling MRI in measuring blood perfusion in the human eye.J. Magn. Reson. Imaging201949496697410.1002/jmri.2632330252997
     [Google Scholar]
  7. MalekiN. AlsopD.C. DaiW. HudsonC. HanJ.S. FisherJ. MikulisD. The effect of hypercarbia and hyperoxia on the total blood flow to the retina as assessed by magnetic resonance imaging.Invest. Ophthalmol. Vis. Sci.20115296867687410.1167/iovs.10‑676221447683
     [Google Scholar]
  8. ZhangY. HarrisonJ.M. NaterasO.S.E. ChalfinS. DuongT.Q. Decreased retinal–choroidal blood flow in retinitis pigmentosa as measured by MRI.Doc. Ophthalmol.2013126318719710.1007/s10633‑013‑9374‑123408312
     [Google Scholar]
  9. Emeterio NaterasO.S. HarrisonJ.M. MuirE.R. ZhangY. PengQ. ChalfinS. GutierrezJ.E. JohnsonD.A. KielJ.W. DuongT.Q. Choroidal blood flow decreases with age: An MRI study.Curr. Eye Res.201439101059106710.3109/02713683.2014.89299724655028
     [Google Scholar]
  10. MuirE.R. RenteríaR.C. DuongT.Q. Reduced ocular blood flow as an early indicator of diabetic retinopathy in a mouse model of diabetes.Invest. Ophthalmol. Vis. Sci.201253106488649410.1167/iovs.12‑975822915034
     [Google Scholar]
  11. WangH. SunJ. LiJ. LiH. WangY. WangZ. Ocular blood flow measurements in diabetic retinopathy using 3D pseudocontinuous arterial spin labeling.J. Magn. Reson. Imaging202153379179810.1002/jmri.2739833140547
     [Google Scholar]
  12. ChenY. FengX. HuangY. ZhaoL. ChenX. QinS. SunJ. JingJ. ZhangX. WangY. Blood flow perfusion in visual pathway detected by arterial spin labeling magnetic resonance imaging for differential diagnosis of ocular ischemic syndrome.Front. Neurosci.202317112149010.3389/fnins.2023.112149036860621
     [Google Scholar]
  13. LiH. SunJ. WangH. WangY. WangZ. LiJ. Evaluation of hemodynamic changes in nonarteritic anterior ischemic optic neuropathy using multimodality imaging.Quant. Imaging Med. Surg.20211151932194510.21037/qims‑20‑69933936976
     [Google Scholar]
  14. CaiL. NiuH. RenP. LiuY. ZhangT. LiuD. ZhaoE. ZhuL. LiJ. QiaoP. ZhengW. WangZ. The effect of dobutamine on ocular blood flow of healthy adults: A 3D pseudocontinuous aterial spin labelling study.Front. Physiol.202213100391510.3389/fphys.2022.100391536523560
     [Google Scholar]
  15. ChenH. TanM.H. PomerleauD. ChongE.W. LimL.L. SymonsR.C.A. Optical coherence tomography analysis of patients with untreated diabetic macular edema.Graefes Arch. Clin. Exp. Ophthalmol.2020258365366110.1007/s00417‑019‑04549‑y31879819
     [Google Scholar]
  16. JohannesenS.K. VikenJ.N. VergmannA.S. GrauslundJ. Optical coherence tomography angiography and microvascular changes in diabetic retinopathy: A systematic review.Acta Ophthalmol.201997171410.1111/aos.1385930238633
     [Google Scholar]
  17. HwangD.J. LeeE.J. LeeS.Y. ParkK.H. WooS.J. Effect of diabetic macular edema on peripapillary retinal nerve fiber layer thickness profiles.Invest. Ophthalmol. Vis. Sci.20145574213421910.1167/iovs.13‑1377624833740
     [Google Scholar]
  18. CuypersM.H.M. KasanardjoJ.S. PolakB.C.P. Retinal blood flow changes in diabetic retinopathy measured with the Heidelberg scanning laser Doppler flowmeter.Graefes Arch. Clin. Exp. Ophthalmol.20002381293594110.1007/s00417000020711196354
     [Google Scholar]
  19. LeeJ. MoonB.G. ChoA.R. YoonY.H. Optical coherence tomography angiography of DME and its association with anti-VEGF treatment response.Ophthalmology2016123112368237510.1016/j.ophtha.2016.07.01027613201
     [Google Scholar]
  20. DasA. McGuireP.G. RangasamyS. Diabetic macular edema: Pathophysiology and novel therapeutic targets.Ophthalmology201512271375139410.1016/j.ophtha.2015.03.02425935789
     [Google Scholar]
  21. TotanY. AkyüzT.K. GülerE. GüragaçF.B. Evaluation of ocular pulse amplitude and choroidal thickness in diabetic macular edema.Eye201630336937410.1038/eye.2015.23226563658
     [Google Scholar]
  22. KaseS. EndoH. TakahashiM. ItoY. SaitoM. YokoiM. KatsutaS. SonodaS. SakamotoT. IshidaS. KaseM. Alteration of choroidal vascular structure in diabetic macular edema.Graefes Arch. Clin. Exp. Ophthalmol.2020258597197710.1007/s00417‑020‑04604‑z32002623
     [Google Scholar]
  23. KimJ.T. LeeD.H. JoeS.G. KimJ.G. YoonY.H. Changes in choroidal thickness in relation to the severity of retinopathy and macular edema in type 2 diabetic patients.Invest. Ophthalmol. Vis. Sci.20135453378338410.1167/iovs.12‑1150323611988
     [Google Scholar]
  24. SunZ. TangF. WongR. LokJ. SzetoS.K.H. ChanJ.C.K. ChanC.K.M. ThamC.C. NgD.S. CheungC.Y. OCT angiography metrics predict progression of diabetic retinopathy and development of diabetic macular edema: A prospective study.Ophthalmology2019126121675168410.1016/j.ophtha.2019.06.01631358386
     [Google Scholar]
  25. MuirE.R. De La GarzaB. DuongT.Q. Blood flow and anatomical MRI in a mouse model of retinitis pigmentosa.Magn. Reson. Med.201369122122810.1002/mrm.2423222392583
     [Google Scholar]
  26. LiG. ShihY.Y.I. KielJ.W. De La GarzaB.H. DuF. DuongT.Q. MRI study of cerebral, retinal and choroidal blood flow responses to acute hypertension.Exp. Eye Res.201311211812410.1016/j.exer.2013.04.00323623996
     [Google Scholar]
  27. PengQ. ZhangY. NaterasO.S.E. van OschM.J.P. DuongT.Q. MRI of blood flow of the human retina.Magn. Reson. Med.20116561768177510.1002/mrm.2276321590806
     [Google Scholar]
  28. ZhangY. NaterasO.S.E. PengQ. RosendeC.A. DuongT.Q. Blood flow MRI of the human retina/choroid during rest and isometric exercise.Invest. Ophthalmol. Vis. Sci.20125374299430510.1167/iovs.11‑938422661466
     [Google Scholar]
  29. WuB. LouX. WuX. MaL. Intra‐ and interscanner reliability and reproducibility of 3D whole‐brain pseudo‐continuous arterial spin‐labeling MR perfusion at 3T.J. Magn. Reson. Imaging201439240240910.1002/jmri.2417523723043
     [Google Scholar]
  30. LouX. MaX. LiebeskindD.S. MaN. TianC. LyuJ. LongX. MaL. WangD.J.J. Collateral perfusion using arterial spin labeling in symptomatic versus asymptomatic middle cerebral artery stenosis.J. Cereb. Blood Flow Metab.201939110811710.1177/0271678X1772521228786338
     [Google Scholar]
  31. LiuY. ZengX. WangZ. ZhangN. FanD. YuanH. Different post label delay cerebral blood flow measurements in patients with Alzheimer’s disease using 3D arterial spin labeling.Magn. Reson. Imaging20153391019102510.1016/j.mri.2015.05.00126113261
     [Google Scholar]
  32. KhatriM. SaxenaS. KaurA. BhaskerS.K. KumarM. MeyerC.H. Resistive index of ophthalmic artery correlates with retinal pigment epithelial alterations on spectral domain optical coherence tomography in diabetic retinopathy.Int. J. Retina Vitreous2018411210.1186/s40942‑018‑0116‑029657836
     [Google Scholar]
  33. KatoN. HarutaM. FurushimaK. AraiR. MatsuoY. YoshidaS. Decrease in ocular blood flow thirty minutes after intravitreal injections of brolucizumab and aflibercept for neovascular age-related macular degeneration.Clin. Ophthalmol.2023171187119210.2147/OPTH.S40724937096209
     [Google Scholar]
  34. Ghasemi FalavarjaniK. IafeN.A. HubschmanJ.P. TsuiI. SaddaS.R. SarrafD. Optical coherence tomography angiography analysis of the foveal avascular zone and macular vessel density after anti-vegf therapy in eyes with diabetic macular edema and retinal vein occlusion.Invest. Ophthalmol. Vis. Sci.2017581303410.1167/iovs.16‑2057928114569
     [Google Scholar]
/content/journals/cmir/10.2174/0115734056307305240403060707
Loading
Evaluating Ocular Blood Flow in Diabetic Macular Edema using Three-dimensional Pseudocontinuous Arterial Spin Labeling
Curr. Med. Imaging 20, e15734056307305 (2024); https://doi.org/10.2174/0115734056307305240403060707
/content/journals/cmir/10.2174/0115734056307305240403060707
/content/journals/cmir/10.2174/0115734056307305240403060707
Loading

Data & Media loading...


  • Article Type:     Research Article
Keyword(s): Arterial spin labeling; Diabetes; Diabetic macular edema; Magnetic resonance imaging; Ocular blood flow; Retinopathy

Most Cited Most Cited RSS feed

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error
Please enter a valid_number test