Skip to content
2000
  1. Home
  2. A-Z Publications
  3. Current Medical Imaging
  4. Volume 20, Issue 1
  5. Article
Volume 20, Issue 1
  • ISSN: 1573-4056
  • E-ISSN: 1875-6603
file format pdf download PDF
side by side viewer icon HTML

Abstract

Objective

This study aims to investigate the association of preoperative body composition parameters, measured by computed tomography in patients undergoing surgery for renal cell carcinoma, with its stage and to survey the relationship with postoperative hospitalization duration and survival.

Methods

Demographic data, pathology results, cancer stages, and hospitalization duration of 104 patients undergoing surgery at the urology clinic due to renal cell carcinoma between 2019 and 2023 were analyzed retrospectively. On computed tomography scans acquired during diagnosis, visceral adipose tissue, subcutaneous adipose tissue, total adipose tissue, and skeletal muscle area were measured. The ratios of body composition parameters were computed.

Results

When the correlation between survival time and body composition in deceased patients was analysed, a moderate but significant correlation was observed between skeletal muscle area value and total adipose tissue / skeletal muscle area ratio (r=0.630, p=0.001; r=0.598, p=0.002). A significant and strong correlation was observed between total adipose tissue value and survival (r=0.704, p<0.001). Subcutaneous adipose tissue / skeletal muscle area was found to be an independent risk factor associated with mortality, and a ratio of 0.98 or less increased the mortality risk approximately 16-fold.

Conclusion

The relationship between body composition parameters measured by computed tomography, which can be easily evaluated pre-treatment, and mortality, postoperative recovery and length of hospital stay can be evaluated, giving clinicians an idea about the potential difficulties that patients may encounter during the treatment process. For this purpose, the subcutaneous adipose tissue / skeletal muscle area ratio is the most helpful parameter that can be used.

© 2024 The Author(s). Published by Bentham Science Publisher.
This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: https://creativecommons.org/licenses/by/4.0/legalcode. This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Loading

Article metrics loading...

/content/journals/cmir/10.2174/0115734056301569240322083100
2024-01-01
2025-06-24

  • From This Site

    /content/journals/cmir/10.2174/0115734056301569240322083100
    dcterms_title,dcterms_subject,pub_keyword
    -contentType:Contributor -contentType:Concept -contentType:Institution
    10
    5
The full text of this item is not currently available.

References

  1. DhôteR. Pellicer-coeuretM. ThiounnN. DebréB. Vidal-trecanG. Risk factors for adult renal cell carcinoma: A systematic review and implications for prevention.BJU Int.2000861202710.1046/j.1464‑410x.2000.00708.x10886077
     [Google Scholar]
  2. BahadoramS. DavoodiM. HassanzadehS. BahadoramM. BarahmanM. MafakherL. Renal cell carcinoma: An overview of the epidemiology, diagnosis, and treatment.G. Ital. Nefrol.2022393135819037
     [Google Scholar]
  3. CapitanioU. BensalahK. BexA. BoorjianS.A. BrayF. ColemanJ. GoreJ.L. SunM. WoodC. RussoP. Epidemiology of renal cell carcinoma.Eur. Urol.2019751748410.1016/j.eururo.2018.08.03630243799
     [Google Scholar]
  4. MauritsJ.S.F. Body Composition and Clinical Outcomes in Renal Cell Cancer.Nijmegen, NLRadboud University Nijmegen2023
     [Google Scholar]
  5. NabiS. KesslerE.R. BernardB. FlaigT.W. LamE.T. Renal cell carcinoma: A review of biology and pathophysiology.F1000Res.2018730710.12688/f1000research.13179.1
     [Google Scholar]
  6. FukushimaH. NakanishiY. KataokaM. TobisuK. KogaF. Postoperative Changes in skeletal muscle mass predict survival of patients with metastatic renal cell carcinoma undergoing cytoreductive nephrectomy.Clin. Genitourin. Cancer2017152e229e23810.1016/j.clgc.2016.08.00427601279
     [Google Scholar]
  7. SchmeusserB.N. PatilD.H. MidenbergE. HigginsM.I. ZaldumbideJ. MartiniD.J. SteeleS. WilliamsM. NabavizadehR. PsutkaS.P. OganK. BilenM.A. MasterV.A. Data regarding covariates significantly associated with sarcopenia and varying albumin statuses in patients with renal cell carcinoma.Data Brief20224510872410.1016/j.dib.2022.10872436426052
     [Google Scholar]
  8. HuX. LiaoD.W. YangZ.Q. YangW.X. XiongS.C. LiX. Sarcopenia predicts prognosis of patients with renal cell carcinoma: A systematic review and meta-analysis.Int. Braz J Urol202046570571510.1590/s1677‑5538.ibju.2019.063632213202
     [Google Scholar]
  9. VrielingA. KampmanE. KnijnenburgN.C. MuldersP.F. SedelaarJ.P.M. BaracosV.E. KiemeneyL.A. Body composition in relation to clinical outcomes in renal cell cancer: A systematic review and meta-analysis.Eur. Urol. Focus20184342043410.1016/j.euf.2016.11.00928753824
     [Google Scholar]
  10. DemirelE. DilekO. A new finding for the obesity paradox? Evaluation of the relationship between muscle and adipose tissue in nuclear grade prediction in patients with clear cell renal cell carcinoma.Acta Radiol.20236441659166710.1177/0284185122112635837023029
     [Google Scholar]
  11. LeeM.H. PickhardtS.G. GarrettJ.W. PerezA.A. ZeaR. ValleK.F. LubnerM.G. BatesD.D.B. SummersR.M. PickhardtP.J. Utility of fully automated body composition measures on pretreatment abdominal CT for predicting survival in patients with colorectal cancer.AJR Am. J. Roentgenol.2023220337138010.2214/AJR.22.2804336000663
     [Google Scholar]
  12. LuJ. ZhengZ.F. LiP. XieJ.W. WangJ.B. LinJ.X. ChenQ.Y. CaoL.L. LinM. TuR.H. ZhengC.H. HuangC.M. A novel preoperative skeletal muscle measure as a predictor of postoperative complications, long-term survival and tumor recurrence for patients with gastric cancer after radical gastrectomy.Ann. Surg. Oncol.201825243944810.1245/s10434‑017‑6269‑529181681
     [Google Scholar]
  13. van VugtJ.L.A. Coebergh van den BraakR.R.J. LalmahomedZ.S. VrijlandW.W. DekkerJ.W.T. ZimmermanD.D.E. VlesW.J. CoeneP.P.L.O. IJzermansJ.N.M. Impact of low skeletal muscle mass and density on short and long-term outcome after resection of stage I-III colorectal cancer.Eur. J. Surg. Oncol.20184491354136010.1016/j.ejso.2018.05.02929914788
     [Google Scholar]
  14. Silva de PaulaN BrunoKDA AredesMA ChavesGV Sarcopenia and skeletal muscle quality as predictors of postoperative complication and early mortality in gynecologic cancer.Int J Gynecol Cancer201828241242010.1097/IGC.0000000000001157
     [Google Scholar]
  15. HamaguchiY. KaidoT. OkumuraS. KobayashiA. FujimotoY. OgawaK. MoriA. HammadA. HatanoE. UemotoS. Muscle steatosis is an independent predictor of postoperative complications in patients with hepatocellular carcinoma.World J. Surg.20164081959196810.1007/s00268‑016‑3504‑327071610
     [Google Scholar]
  16. PeytonC.C. HeavnerM.G. RagueJ.T. KraneL.S. HemalA.K. Does sarcopenia impact complications and overall survival in patients undergoing radical nephrectomy for Stage III and IV kidney cancer?J. Endourol.201630222923610.1089/end.2015.049226418428
     [Google Scholar]
  17. ChengX. ZhangY. WangC. DengW. WangL. DuanmuY. LiK. YanD. XuL. WuC. ShenW. TianW. The optimal anatomic site for a single slice to estimate the total volume of visceral adipose tissue by using the quantitative computed tomography (QCT) in Chinese population.Eur. J. Clin. Nutr.201872111567157510.1038/s41430‑018‑0122‑129559725
     [Google Scholar]
  18. FujiwaraN. NakagawaH. KudoY. TateishiR. TaguriM. WatadaniT. NakagomiR. KondoM. NakatsukaT. MinamiT. SatoM. UchinoK. EnookuK. KondoY. AsaokaY. TanakaY. OhtomoK. ShiinaS. KoikeK. Sarcopenia, intramuscular fat deposition, and visceral adiposity independently predict the outcomes of hepatocellular carcinoma.J. Hepatol.201563113114010.1016/j.jhep.2015.02.03125724366
     [Google Scholar]
  19. KanekoG. MiyajimaA. YugeK. YazawaS. MizunoR. KikuchiE. JinzakiM. OyaM. Visceral obesity is associated with better recurrence-free survival after curative surgery for Japanese patients with localized clear cell renal cell carcinoma.Japan. J. Clin. Oncol.201545221021610.1093/jjco/hyu19325420691
     [Google Scholar]
  20. FainJ.N. MadanA.K. HilerM.L. CheemaP. BahouthS.W. Comparison of the release of adipokines by adipose tissue, adipose tissue matrix, and adipocytes from visceral and subcutaneous abdominal adipose tissues of obese humans.Endocrinology200414552273228210.1210/en.2003‑133614726444
     [Google Scholar]
  21. EbadiM. MazurakV. Evidence and mechanisms of fat depletion in cancer.Nutrients20146115280529710.3390/nu611528025415607
     [Google Scholar]
  22. PorterS.A. MassaroJ.M. HoffmannU. VasanR.S. O’DonnelC.J. FoxC.S. Abdominal subcutaneous adipose tissue: A protective fat depot?Diabetes Care20093261068107510.2337/dc08‑228019244087
     [Google Scholar]
/content/journals/cmir/10.2174/0115734056301569240322083100
Loading
The Association of Body Composition Parameters Measured by Computed Tomography with Cancer Stage, Prognosis, and Survival in Patients with Renal Cell Carcinoma
Curr. Med. Imaging 20, e15734056301569 (2024); https://doi.org/10.2174/0115734056301569240322083100
/content/journals/cmir/10.2174/0115734056301569240322083100
/content/journals/cmir/10.2174/0115734056301569240322083100
Loading

Data & Media loading...


  • Article Type:     Research Article
Keyword(s): Computed tomography; Metastatic; Renal cell cancer; Skeletal muscle area (SMA); Subcutaneous adipose tissue (SAT); Visceral adipose tissue (VAT)

Most Cited Most Cited RSS feed

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error
Please enter a valid_number test