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Volume 20, Issue 1
  • ISSN: 1573-4056
  • E-ISSN: 1875-6603
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Abstract

Background

Intravoxel incoherent motion diffusion-weighted imaging (IVIM-DWI) is considered a potential marker of hepatic fibrosis (HF).

Objective

To explore the influencing factors of repeatability and reliability in IVIM-DWI parameters of ROI-based liver segments in participants with HF and healthy volunteers (HV) and to assess the diagnostic efficiency of these parameters in HF.

Methods

Participants with early HF (EHF, n=59) or advanced HF (AHF, n=38) and HV (n=48) were recruited. Two examiners measured IVIM data using mono-, bi-exponential and stretched exponential models. The results and influencing factors of repeatability and reliability of IVIM-DWI, and the diagnostic efficiency were analyzed.

Results

The repeatability of D* (CV: 26.62–41.47%) and DDC (CV: 18.01–34.40%) was poor, the repeatability of ADC (CV: 4.95–9.76%), D (CV: 7.09–15.52%), (CV: 9.35–17.15%), and α (CV: 7.48–13.81%) was better; ordered logistic regression showed statistically significant results of IVIM-derived parameters; the reliability showed no obvious trend, and ordered logistic regression showed statistically significant results of IVIM-derived parameters, groups, and partial hepatic segments (all <0.001). IVIM-derived parameters with relatively good repeatability (CV<20%) and reliability (ICC>0.4) were used to establish regression models for differential diagnosis. The AUC of regression models was 0.744–0.783 (EHF . AHF), but no statistically significant parameters were found in the HV F comparison.

Conclusion

IVIM-derived parameters were the most important factors affecting the repeatability and reliability, while staging of HF and hepatic segments may be the influencing factors of reliability. IVIM-derived parameters showed medium diagnostic efficiency in distinguishing between EHF and AHF.

Trial Registration

Registered on Clinical Trial Management Public Platform (registration code: ChiCTR2100052114, date: 17th Oct. 2021).

© 2024 Huang et al.
This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: https://creativecommons.org/licenses/by/4.0/legalcode. This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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2024-01-01
2025-06-21

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/content/journals/cmir/10.2174/0115734056288517240221113847
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Effect of Liver Segments and Hepatic Fibrosis Grade on Repeatability, Reliability, and Diagnostic Efficiency of Intravoxel Incoherent Motion
Curr. Med. Imaging 20, e15734056288517 (2024); https://doi.org/10.2174/0115734056288517240221113847
/content/journals/cmir/10.2174/0115734056288517240221113847
/content/journals/cmir/10.2174/0115734056288517240221113847
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  • Article Type:     Research Article
Keyword(s): Diffusion weighted imaging; Hepatic fibrosis; IVIM-DWI; Liver segment; Reliability; Repeatability

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