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Volume 20, Issue 1
  • ISSN: 1573-4056
  • E-ISSN: 1875-6603
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Abstract

Background

To investigate the optimal B value of renal amide proton transfer-weighted (APTw) images and the reproducibility of this value, and to explore the utility of APT imaging of renal masses and kidney tissues.

Methods

APTw images with different B values were repeatedly recorded in 15 healthy volunteers to determine the optimal value. Two 4-point Likert scales (poor [1] to excellent [4]) were used to evaluate contour clarity and artifacts in masses and normal tissues. The APTw values of masses and normal tissues were then compared in evaluable images (contour clarity score > 1, artifacts score > 1). The APTw of malignant masses, normal tissues, and benign masses were calculated and compared with the Mann-Whitney U test.

Results

The optimal scanning parameter of B was 2 μT, and the APTw images had good agreement in the volunteers. Our study of APTw imaging examined 70 renal masses (13 benign, 57 malignant) and 49 normal kidneys (including those from 15 healthy volunteers). The mean APTw value for renal malignant masses (2.28(1.55)) was different from that for benign masses (0.91(1.30)) (<0.001), renal cortex (1.30 (1.25)) (<0.001), renal medulla (1.64 (1.33)) (<0.05), and renal pelvis (5.49 (2.65)) (<0.001).

Conclusion

These preliminary data demonstrate that APTw imaging of the kidneys has potential use as an imaging biomarker for the differentiation of normal tissues, malignant masses, and benign masses.

© 2024 Xu et al.
This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: https://creativecommons.org/licenses/by/4.0/legalcode. This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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2024-01-01
2025-06-01

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/content/journals/cmir/10.2174/0115734056284650240325044027
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Feasibility of Amide Proton Transfer-weighted Imaging at 3T for Renal Masses: A Preliminary Study
Curr. Med. Imaging 20, e15734056284650 (2024); https://doi.org/10.2174/0115734056284650240325044027
/content/journals/cmir/10.2174/0115734056284650240325044027
/content/journals/cmir/10.2174/0115734056284650240325044027
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  • Article Type:     Research Article
Keyword(s): Amide proton transfer-weighted (APTw); CT; Imaging kidney tissues; Magnetic resonance imaging (MRI); Renal masses

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