Skip to content
2000
Volume 20, Issue 1
  • ISSN: 1573-4056
  • E-ISSN: 1875-6603

Abstract

Background

Embryonal carcinoma is a rare tissue type in germ cell tumors. According to our literature review, metastatic embryonal carcinoma misdiagnosed as lymphoma because of its high similarity to lymphoma is extremely rare and has not been reported yet.

Case Presentation

A 46-year-old middle adulthood male presented with unexplained fever, night sweats, abdominal distension for 3 months, and weight loss of around 7kg during almost 6 months, which is extremely similar to lymphoma from the clinical features and imaging examinations. After a clear diagnosis, the case not only obtained the opportunity of surgery but was also exempted from radiotherapy. The treatment effect was good. We report a case of rare metastatic embryonal carcinoma, which can provide insight into the diagnosis and treatment of embryonal carcinoma.

Conclusion

Metastatic embryonal carcinoma of abdominal lymph nodes can be highly similar to lymphoma; the diagnosis can only be based on clinical manifestations and imaging examination but also combined with patient history, tumor markers and biochemical examination. However, the final diagnosis depends on pathological biopsy.

This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: https://creativecommons.org/licenses/by/4.0/legalcode. This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Loading

Article metrics loading...

/content/journals/cmir/10.2174/0115734056283964240228074032
2024-01-01
2025-04-23
The full text of this item is not currently available.

References

  1. NumanamiH. TakahashiD. TakahashiE. KatsudaE. KameiS. NaruseK. BabaK. HaniudaM. YokoiT. YamaguchiE. KuboA. Metastatic embryonal carcinoma mimicking locally advanced non-small cell lung cancer.Intern. Med.2015541596110.2169/internalmedicine.54.288425742895
    [Google Scholar]
  2. ZhangH. LiuF. WeiJ. XueD. XieZ. XuC. Mixed germ cell tumor of the endometrium: A case report and literature review.Open Med.2020151657010.1515/med‑2020‑001032064359
    [Google Scholar]
  3. SiegelR.L. MillerK.D. FuchsH.E. JemalA. Cancer statistics, 2021.CA Cancer J. Clin.202171173310.3322/caac.2165433433946
    [Google Scholar]
  4. ParkJ.S. KimJ. ElghiatyA. HamW.S. Recent global trends in testicular cancer incidence and mortality.Medicine20189737e1239010.1097/MD.000000000001239030213007
    [Google Scholar]
  5. IdreesM.T. UlbrightT.M. OlivaE. YoungR.H. MontironiR. EgevadL. BerneyD. SrigleyJ.R. EpsteinJ.I. TickooS.K. The World Health Organization 2016 classification of testicular non‐germ cell tumours: A review and update from the international society of urological pathology testis consultation panel.Histopathology201770451352110.1111/his.1311527801954
    [Google Scholar]
  6. RobertsonP.L. DaRossoR.C. DaRossoR.C. AllenJ.C. AllenJ.C. Improved prognosis of intracranial non-germinoma germ cell tumors with multimodality therapy.J. Neurooncol.1997321718010.1023/A:10057321057279049865
    [Google Scholar]
  7. AlbersP. AlbrechtW. AlgabaF. BokemeyerC. Cohn-CedermarkG. FizaziK. HorwichA. LagunaM.P. EAU testicular cancer clinical guideline: 2011 update.Actas Urol. Esp.201236312714510.1016/j.acuro.2011.06.01722188753
    [Google Scholar]
  8. PangC. GuanY. LiH. ChenW. ZhuG. Urologic cancer in China.Jpn. J. Clin. Oncol.201646649750110.1093/jjco/hyw03427049022
    [Google Scholar]
  9. ManciniM. CarmignaniL. GazzanoG. SagoneP. GaddaF. BosariS. RoccoF. ColpiG.M. High prevalence of testicular cancer in azoospermic men without spermatogenesis.Hum. Reprod.20072241042104610.1093/humrep/del50017220165
    [Google Scholar]
  10. HungT.J. McLeanL. MitchellC. PascoeC. LawrentschukN. MurphyD.G. IravaniA. SinghD. HofmanM.S. ZidanL. AkhurstT. LewinJ. HicksR.J. The role of 18F-FDG-PET/CT in evaluating retroperitoneal masses -Keeping your eye on the ball!Cancer Imaging20191912810.1186/s40644‑019‑0217‑531142361
    [Google Scholar]
  11. Müller-MattheisV. ReinhardtM. GerharzC.D. FürstG. VosbergH. GärtnerM.H.W. AckermannR. Positron-emission tomography with 18F-2-fluoro-2-deoxy-D-glucose (18FDG-PET) in the diagnosis of retroperitoneal lymph-node metastases from testicular tumors.Urologe A199837660962010.1007/s0012000502239887489
    [Google Scholar]
  12. ChenH. YinG. CuiN. LinH. Rare primary embryonal carcinoma in the brachial plexus: A case report and literature review.Neurosurgery2020872E152E15510.1093/neuros/nyz36131555806
    [Google Scholar]
  13. RodriguezS.L. KostickD.A. HeredR.W. JoyceM.J. Primary embryonal carcinoma of the orbit in a 10-month-old female: A seven-year follow-up.Am. J. Ophthalmol.2005139238038110.1016/j.ajo.2004.08.02615734016
    [Google Scholar]
  14. MasakiS. TakimotoH. AritaN. UshioY. MogamiH. Total removal of embryonal carcinoma in the pineal region--Case report and review of the literature.Neurol. Med. Chir.198525757157710.2176/nmc.25.5712415853
    [Google Scholar]
  15. HattabE.M. TuP.H. WilsonJ.D. ChengL. OCT4 immunohistochemistry is superior to placental alkaline phosphatase (PLAP) in the diagnosis of central nervous system germinoma.Am. J. Surg. Pathol.200529336837110.1097/01.pas.0000149709.19958.a715725806
    [Google Scholar]
  16. CaoD. LiJ. GuoC.C. AllanR.W. HumphreyP.A. SALL4 is a novel diagnostic marker for testicular germ cell tumors.Am. J. Surg. Pathol.20093371065107710.1097/PAS.0b013e3181a13eef19390421
    [Google Scholar]
  17. MeiK. LiuA. AllanR.W. WangP. LaneZ. AbelT.W. WeiL. ChengH. GuoS. PengY. RakhejaD. WangM. MaJ. RodriguezM.M. LiJ. CaoD. Diagnostic utility of SALL4 in primary germ cell tumors of the central nervous system: A study of 77 cases.Mod. Pathol.200922121628163610.1038/modpathol.2009.14819820689
    [Google Scholar]
  18. OldenburgJ. BerneyD.M. BokemeyerC. ClimentM.A. DaugaardG. GietemaJ.A. De GiorgiU. HaugnesH.S. HuddartR.A. LeãoR. SohaibA. GillessenS. PowlesT. Testicular seminoma and non-seminoma: ESMO-EURACAN clinical practice guideline for diagnosis, treatment and follow-up.Ann. Oncol.202233436237510.1016/j.annonc.2022.01.00235065204
    [Google Scholar]
  19. GiannatempoP. GrecoT. MarianiL. NicolaiN. TanaS. FarèE. RaggiD. PivaL. CatanzaroM. BiasoniD. TorelliT. StagniS. AvuzziB. MaffezziniM. LandoniG. De BraudF. GianniA.M. SonpavdeG. SalvioniR. NecchiA. Radiotherapy or chemotherapy for clinical stage IIA and IIB seminoma: A systematic review and meta-analysis of patient outcomes.Ann. Oncol.201526465766810.1093/annonc/mdu44725214543
    [Google Scholar]
  20. HallemeierC.L. PisanskyT.M. DavisB.J. ChooR. Long-term outcomes of radiotherapy for stage II testicular seminoma–the Mayo Clinic experience.Urol. Oncol.20133181832183810.1016/j.urolonc.2012.03.01022537538
    [Google Scholar]
  21. CapitanioU. JeldresC. PerrotteP. IsbarnH. CrépelM. CloutierV. GagneB.S. ShariatS.F. DuclosA. ArjaneP. WidmerH. SaadF. MontorsiF. KarakiewiczP.I. Population-based study of perioperative mortality after retroperitoneal lymphadenectomy for nonseminomatous testicular germ cell tumors.Urology200974237337710.1016/j.urology.2009.01.08519501893
    [Google Scholar]
/content/journals/cmir/10.2174/0115734056283964240228074032
Loading
/content/journals/cmir/10.2174/0115734056283964240228074032
Loading

Data & Media loading...


  • Article Type:
    Case Report
Keyword(s): Diagnose; Embryonal carcinoma; Germinoma; Lymphoma; Testicular neoplasms; Therapy
This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error
Please enter a valid_number test