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- Volume 29, Issue 27, 2022
Current Medicinal Chemistry - Volume 29, Issue 27, 2022
Volume 29, Issue 27, 2022
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Glycogen Synthase Kinase 3β Involvement in Neuroinflammation and Neurodegenerative Diseases
Background: GSK-3β activity has been strictly related to neuroinflammation and neurodegeneration. Alzheimer’s disease is the most studied neurodegenerative disease, but GSK-3β seems to be involved in almost all neurodegenerative diseases, including Parkinson’s disease, amyotrophic lateral sclerosis, frontotemporal dementia, Huntington’s disease, and the autoimmune disease multiple sclerosis. Objective: This review Read More
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Casein Kinase 1δ Inhibitors as Promising Therapeutic Agents for Neurodegenerative Disorders
Casein kinase 1 (CK1) belongs to the serine-threonine kinase family and is expressed in all eukaryotic organisms. At least six human isoforms of CK1 (termed α, γ1-3, δ and ) have been cloned and characterized. CK1δ isoform modulates several physiological processes, including DNA damage repair, circadian rhythm, cellular proliferation and apoptosis. Therefore, CK1δ dysfunction may trigger diverse pathologies, such as canc Read More
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Role of Fyn Kinase Inhibitors in Switching Neuroinflammatory Pathways
Authors: Giambattista Marotta, Filippo Basagni, Michela Rosini and Anna MinariniFyn kinase is a member of the Src non-receptor tyrosine kinase family. Fyn is involved in multiple signaling pathways extending from cell proliferation and differentiation to cell adhesion and cell motility, and it has been found to be overexpressed in various types of cancers. In the central nervous system, Fyn exerts several different functions such as axon–glial signal transduction, oligodendrocyte maturation, and m Read More
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Computational Strategies to Identify New Drug Candidates against Neuroinflammation
Authors: Matteo Pavan, Davide Bassani, Giovanni Bolcato, Maicol Bissaro, Mattia Sturlese and Stefano MoroIncreasing application of computational approaches in these last decades has deeply modified the process of discovery and commercialization of new therapeutic entities. This is especially true in the field of neuroinflammation, in which both the peculiar anatomical localization and the presence of the blood-brain barrier make it mandatory to finely tune the candidates’ physicochemical properties from the early stages o Read More
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Volumes & issues
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Volume 32 (2025)
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Volume 31 (2024)
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Volume 30 (2023)
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Volume 29 (2022)
- Issue 42
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- Issue 1
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Volume 28 (2021)
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Volume 27 (2020)
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Volume 26 (2019)
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Volume 25 (2018)
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Volume 24 (2017)
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Volume 23 (2016)
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Volume 22 (2015)
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Volume 21 (2014)
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Volume 20 (2013)
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Volume 19 (2012)
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Volume 18 (2011)
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Volume 17 (2010)
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Volume 16 (2009)
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Volume 15 (2008)
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Volume 14 (2007)
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Volume 13 (2006)
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Volume 12 (2005)
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Volume 11 (2004)
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Volume 10 (2003)
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Volume 9 (2002)
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Volume 8 (2001)
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Volume 7 (2000)
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