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- Volume 29, Issue 41, 2022
Current Medicinal Chemistry - Volume 29, Issue 41, 2022
Volume 29, Issue 41, 2022
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Enzymatic Strategies for the Preparation of Pharmaceutically Important Amino Acids through Hydrolysis of Amino Carboxylic Esters and Lactams
Authors: Enikő Forró and Ferenc Fülö pThe most relevant lipase-catalyzed strategies for the synthesis of pharmaceutically important cyclic and acyclic α-, β- and γ-amino carboxylic acid enantiomers through hydrolysis of the corresponding amino carboxylic esters and lactams, over the last decade are overviewed. A brief Introduction part deals with the importance and synthesis of enantiomeric amino acids, and formulates the objectives of the actual work Read More
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Structure and Function of Ligand CX3CL1 and its Receptor CX3CR1 in Cancer
By Xinjie LuThe C-X3-C motif chemokine ligand (CX3CL)1 (also known as Fractalkine) and its receptor CX3CR1 (also known as G-protein coupled receptor 13) are expressed on the membranes of many different cells such as epithelial cells, dendritic cells, smooth muscle cells, and neurons. CX3CR1 is primarily expressed on monocytes, macrophages, dendritic cells, T cells, and natural killer cells. The binding of CX3CL1 to CX3CR1 induc Read More
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Current Understanding of Cardiac Troponins Metabolism: A Narrative Review
More LessBackground and Aims: Current methods (highly sensitive and ultra-sensitive) of cardiospecific troponins detection have enabled early diagnosis of myocardial infarction (MI) and selection of optimal treatment tactics for patients early from admission. The use of these methods in real clinical practice helps to choose the most optimal treatment tactics for patients in the early stages after admission, and this significantly improv Read More
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Comprehensive Perspectives for Erectile Dysfunction Pharmacotherapy: From Mechanism to Application
Authors: Haibao Zhang, Guodong Zhu, Haomin Ren, Wenbin Song and Zhishang YangIn recent years, the incidence of erectile dysfunction (ED) has continued to rise worldwide. Since pharmacotherapy is still the most common and effective method for the treatment of ED at present, many methods and drugs have been designed or developed for the treatment of ED. Oral phosphodiesterase-5 inhibitors and androgen supplement therapy are currently the common therapeutics for ED; however, some patien Read More
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An Overview of Synthetic Routes of Pharmaceutically Important Pyranopyrazoles
Authors: Sarosh Iqbal, Shumaila Kiran, Aliza Anwar, Shazia Abrar, Ansa Khalid, Mark G. Moloney and Muhammad N. AkhtarPyranopyrazoles are bicyclic nitrogen-containing heterocycles having broadspectrum bioactivities, which may act as anti-cancer, anti-inflammatory, antibacterial, antifungal, insecticidal and molluscicidal agents. Pyranopyrazoles have become an attractive scaffold for the discovery of new drugs due to the diverse range of bioactivities associated with this nucleus. In this review, we have focused on the medicinal importance of pyr Read More
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Volumes & issues
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Volume 32 (2025)
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Volume 31 (2024)
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Volume 30 (2023)
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Volume 29 (2022)
- Issue 42
- Issue 41
- Issue 40
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- Issue 2
- Issue 1
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Volume 28 (2021)
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Volume 27 (2020)
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Volume 26 (2019)
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Volume 25 (2018)
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Volume 24 (2017)
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Volume 23 (2016)
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Volume 22 (2015)
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Volume 21 (2014)
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Volume 20 (2013)
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Volume 19 (2012)
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Volume 18 (2011)
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Volume 17 (2010)
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Volume 16 (2009)
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Volume 15 (2008)
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Volume 14 (2007)
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Volume 13 (2006)
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Volume 12 (2005)
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Volume 11 (2004)
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Volume 10 (2003)
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Volume 9 (2002)
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Volume 8 (2001)
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Volume 7 (2000)
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