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2000
Volume 1, Issue 1
  • ISSN: 2210-299X
  • E-ISSN: 2210-3007

Abstract

Background

A plant from the Acanthaceae family, T. Ander is geographically distributed throughout Asia and is noted for its diuretic and aphrodisiac properties in Ayurvedic literature. In the last four decades, various research teams have conducted experiments with the plant to screen the plant for hepatoprotective, anti-urolithiasis, diuretic, anti-hypertensive, anti-diabetic, chemoprotective, and anticancer activities along with analgesic and anti-inflammatory activity. Flavonoids, alkaloids, steroids, and triterpenoids are among the phytochemicals separated from different plant components, along with vitamins and minerals.

Objective

Considering the therapeutic value of the plant, focus on using current technology to quantify and confirm the pharmacological effects with and assays was felt and to shed light on investigations.

Results

Relevant analytical tools for characterizing and quantifying phytoconstituents in the plant, along with emphasis on well-established pharmacological screening experiments on parts and whole plant extracts, commercially available formulations of have been elaborated. It has been discussed how to further validate the pharmacological effects using methods and predictions from ADME/T analyses. based Phyto fabricated nanoparticle systems with gold and silver have broadened the use of plant extract as a metal. carrier which minimizesmetal. toxicity to further boost its synergistic effects in response to the growing need for targeted medicine delivery systems.

Conclusión

In light of the necessity to investigate a specific mechanism of action for each of the specific phytoconstituents contained in the plant, the present review summarizes the phytochemical and pharmacological importance of the plant in chronic illness.

© 2023 The Author(s). Published by Bentham Science Publisher. This is an open access article published under CC BY 4.0 https://creativecommons.org/licenses/by/4.0/legalcode
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References

  1. RakshitG. SinghV.K. VichitraA.K. Rajpal ChandraP.K. ChoudhuryS.K. A multi-centric double blind homoeopathic pathogenetic trial of Hygrophila spinosa. Indian J. Res. in Homoeo.20148191810.4103/0974‑7168.129672
    [Google Scholar]
  2. NoorN. SatapathyK.B. Phytodiversity of Dhauligiri hill and its adjoining area, Odisha, India: a floristic approach.Plant Arch.202020120932102
    [Google Scholar]
  3. SreeM.D. JoshnaA. LakshmiS.M. KumarD.S. A review on South Indian edible leafy vegetables.J. Glob. Trends Pharm. Sci.20134412481256
    [Google Scholar]
  4. ChauhanN.S. DixitV.K. Asteracantha longifolia (L.) Nees, Acanthaceae: chemistry, traditional, medicinal uses and its pharmacological activities - a review.Rev. Bras. Farmacogn.201020581281710.1590/S0102‑695X2010005000022
    [Google Scholar]
  5. WahengbamS. KaurG. Review on Plants extract as anti-urolithiatic and pathogenesis of urolithiasis induced by ethylene glycol.Eur. J. Mol. Clin. Med.20207746004615
    [Google Scholar]
  6. SinghMK NagoriK TripathiDK Potential analgesic & anti-pyretic herbal drugs: a comparative review of marketed products.Int. J. Phytomedicine.201023197209
    [Google Scholar]
  7. GaikwadK DagleP ChoughuleP JoshiYM KadamV A review on some nephroprotective medicinal plants.Int. J. Pharm. Sci. Res.2012382451
    [Google Scholar]
  8. RathvaB. PatelB. MauryaJ. BeraK. Standardization and evaluation of some parameters of adaptogenic polyherbal oral dosage form.Int. J. Pharm. Sci. Rev. Res.201742117
    [Google Scholar]
  9. GovindP. SharmaM. Ethnomedicinal plants for prevention and treatment of tumours.Int. J. Green Pharm.200931210.4103/0973‑8258.49367
    [Google Scholar]
  10. MaitiB. Antineoplastic effects of the root extract of Hygrophila spinosa.Proceedings of the International Conference on Current Progress in Medicinal and Aromatic Plant ResearchCalcutta, India199413540
    [Google Scholar]
  11. PalA. PaulA.K. Bacterial endophytes of the medicinal herb Hygrophila spinosa T.Anders and their antimicrobial activity.J. Pharm. Res. Int.2013795806
    [Google Scholar]
  12. KrishnaA. MohananS. Formulation and evaluation of liquid oral suspension of paracetamol using newly isolated and characterized Hygrophila spinosaseed mucilage as suspending agent.Asian J. Pharm. Clin. Res.2018111143744110.22159/ajpcr.2018.v11i11.28856
    [Google Scholar]
  13. DashA.K. DuttaG.K. SardarK.K. SahooG. Ethnomedicinal importance of Hygrophila spinosaT. Anders: A review.Plant Arch.201212159
    [Google Scholar]
  14. PatraA. JhaS. MurthyP. Phytochemical and pharmacological potential of Hygrophila spinosa T. anders.Pharmacogn. Rev.200936330
    [Google Scholar]
  15. NikamD. MundadaS. MishraD. Kokilaksha: A potential ayurvedic herb.Int. J. Res. Ayurveda Pharm.20123678078210.7897/2277‑4343.03616
    [Google Scholar]
  16. SethiyaN.K. AhmedN.M. ShekhR.M. KumarV. Kumar SinghP. KumarV. Ethnomedicinal, phytochemical and pharmacological updates on Hygrophila auriculata (Schum.) Hiene: an overview.J. Integr. Med.201816529931110.1016/j.joim.2018.07.00230007830
    [Google Scholar]
  17. SiljaV.P. VarmaK.S. MohananK.V. Ethnomedicinal plant knowledge of the Mullukuruma tribe of Wayanad district, Kerala.Indian J. Tradit. Knowl.20087604612
    [Google Scholar]
  18. KyawY.M.M. BiY. OoT.N. YangX. Traditional medicinal plants used by the Mon people in Myanmar.J. Ethnopharmacol.202126511325310.1016/j.jep.2020.11325332891817
    [Google Scholar]
  19. GomesA. DasM. DasguptaS.C. Haematinic effect of Hygrophila spinosa T. Anderson on experimental rodents.Indian J. Exp. Biol.200139438138211491586
    [Google Scholar]
  20. ChandaS. BaravaliaY. Screening of some plant extracts against some skin diseases caused by oxidative stress and microorganisms.Afr. J. Biotechnol.201092132103217
    [Google Scholar]
  21. DeyP. SahaM. SenA. Hepatotoxicity and the present herbal hepatoprotective scenario.Int. J. Green Pharm.20137426527310.4103/0973‑8258.122046
    [Google Scholar]
  22. PreethiG.P. GopalakrishnaH.N. RathnakarU.P. DurgaP. ShenoyJ. Acute diuretic activity of alcoholic extracts of Hygrophila auriculata seeds in normal wistar albino rats.Int. J. Pharma Bio Sci.201231283289
    [Google Scholar]
  23. NadkarniK.M. Indian Materia MedicaBombay, IndiaPopular Prakashan1978
    [Google Scholar]
  24. VermaD. SinghS. AryaR. RajanS. AryaB.S. KhuranaA. ManchandaR.K. Morpho-anatomical observations on homoeopathic plant drug Hygrophila spinosa T. Anderson.Pharmacogn. J.201911228629110.5530/pj.2019.11.44
    [Google Scholar]
  25. MisraT.N. SinghR.S. PandeyH.S. SinghB.K. PandeyR.P. Constituents of Asteracantha longifolia. Fitoterapia200172219419610.1016/S0367‑326X(00)00269‑011223236
    [Google Scholar]
  26. AliA. TripathiS.K. A pentacyclic triterpenoid from Asteracantha longifolia Ness.Asian J. Chem.20071953765
    [Google Scholar]
  27. ShahidM. KhanM. HameedA. AshrafM. JamilA. Antioxidant enzymes and inorganic elements in seeds and leaves of four potential medicinal plants from Pakistan.Agrochimica2012566281291
    [Google Scholar]
  28. PatraA. MurthyN.P. JhaS. Pharmacognostical standardization of leaves of Hygrophila spinosaT.Anders.Phcog. J.2009128287
    [Google Scholar]
  29. Perumal SamyR. ManikandanJ. Al QahtaniM. Evaluation of aromatic plants and compounds used to fight multidrug resistant infections.Evid. Based Complement. Alternat. Med.2013201311710.1155/2013/52561324223059
    [Google Scholar]
  30. ParasharV.V. SinghH. Investigation of Astercantha longifolia Nees.Indian J. Pharmacol.1965274109113
    [Google Scholar]
  31. GodboleN.N. GundeB.G. SrivastavaP.D. An investigation of oil from seed of hygrophila spinosa.J. Am. Oil Chem. Soc.1941181020620710.1007/BF02544184
    [Google Scholar]
  32. GovindachariT.R. NagarajanK. PaiB.R. Isolation of lupeol from the root of Asteracantha longifolia Nees.Indian J. of Sci. Res. B.19571672
    [Google Scholar]
  33. ChoudharyB.K. BandyopdhyayN.G. Important of mineral content and medicinal properties of Moringa oleifera and Hygrophila auriculata. Sacitra Ayurveda1980507543549
    [Google Scholar]
  34. GuptaD.R. BhushanR. DhimanR.P. AhmedB. Chemical examination of Asteracantha longifolia. J. Nat. Prod.198346693810.1021/np50030a023
    [Google Scholar]
  35. SatpathyS. PatraA. AhirwarB. Development and validation of a novel high-performance thin-layer chromatography method for the simultaneous determination of apigenin and luteolin in Hygrophila spinosa T. Anders.J. Planar Chromatogr. Mod. TLC201831643744310.1556/1006.2018.31.6.3
    [Google Scholar]
  36. VyasN. RavalM. Quantification of two marker compounds from unsaponifiable matter of Hygrophila spinosaseeds using validated TLC-Densitometric method.Int. J. Pharm. Res2015743946
    [Google Scholar]
  37. HussainA.Z. KumaresanS. GC-MS analysis and antimicrobial activity of Hygrophila auriculata. Arch. Appl. Sci. Res.201355163168
    [Google Scholar]
  38. MajiA.K. MaityN. BanerjiP. BanerjeeD. Validated RP-HPLC-UV method for the determination of betulin in Asteracantha longifolia (L.) Nees. extract.Int. J. Phytomed.201352131135
    [Google Scholar]
  39. MajiA.K. PanditS. BanerjiP. BanerjeeD. A validated RP-HPLC method for simultaneous determination of betulin, lupeol and stigmasterol in Asteracantha longifolia Nees.Int. J. Pharma Sci.201465691695
    [Google Scholar]
  40. JayaprakasamR. RaviT.K. In vitro screening of the biological activity of combined extracts of two medicinal plants and their standardization by validated analytical methods using standard markers.J Pharmacogn Phytochem.2019823052312
    [Google Scholar]
  41. JayaprakasamR. SaleshierM.F. RaviT.K. Standardization of Hygrophila Spinosa and its formulation concerning Lupeol, by developed and validated HPTLC and RP-HPLC Methods.INDIAN DRUGS2015521131910.53879/id.52.01.10182
    [Google Scholar]
  42. SunitaS. AbhishekS. A comparative evaluation of phytochemical fingerprints of Asteracantha longifolia Nees. using HPTLC.Asian J. Plant Sci.20087661161410.3923/ajps.2008.611.614
    [Google Scholar]
  43. HussainM.S. FareedS. AliM. Preliminary phytochemical and pharmacognostical screening of the Ayurvedic drug Hygrophila auriculata (K. Schum). Pharmacogn. J.2011323284010.5530/pj.2011.23.5
    [Google Scholar]
  44. HussainM.S. FareedS. AliM. Simultaneous HPTLC-UV530 nm analysis and validation of bioactive lupeol and stigmasterol in Hygrophila auriculata (K. Schum) Heine.Asian Pac. J. Trop. Biomed.201222S612S61710.1016/S2221‑1691(12)60283‑4
    [Google Scholar]
  45. HussainM.S. FareedS. AliM. Hyphenated chromatographic analysis of bioactive gallic acid and quercetin in Hygrophila auriculata (K. Schum) Heine growing wildly in marshy places in India by validated HPTLC method.Asian Pac. J. Trop. Biomed.201222S477S48310.1016/S2221‑1691(12)60257‑3
    [Google Scholar]
  46. DeattuN. SuseelaL. NarayananN. Chromatographic analysis of polyherbal extract and formulation by HPTLC and GC–MS methods.J. Pharm. Res.20136161010.1016/j.jopr.2012.11.005
    [Google Scholar]
  47. GhuleB. AgrawalP. LalP. KothariD. KotagaleN. Separation and quantification of lupeol in Hygrophila schulli by high-performance thin-layer chromatography.J. Planar Chromatogr. Mod. TLC2021341798710.1007/s00764‑021‑00079‑8
    [Google Scholar]
  48. UshaK. KasturiG.M. HemalathaP. Hepatoprotective effect ofHygrophila spinosa andCassia occidentalis on carbon tetrachloride induced liver damage in experimental rats.Indian J. Clin. Biochem.200722213213510.1007/BF0291333123105700
    [Google Scholar]
  49. RajuB.S. BattuG.R. YBM.L. Antihepatotoxic Activity of Hygrophila Spinosa Roots on CCl4 induced Hepatic Damage in Rats.Pharm. Res.201122-3152155
    [Google Scholar]
  50. SultanaS. AhmedS. SharmaS. KhanN. Asteracantha longifolia suppresses oxidant-induced tissue injury and proliferation in rat liver. Asia Pacific.J. Pharmacol.2006163/4123
    [Google Scholar]
  51. RajV.P. ChandrasekharR.H. PV. S AD. RaoM.C. RaoV.J. NiteshK. In vitro and in vivo hepatoprotective effects of the total alkaloid fraction of Hygrophila auriculata leaves.Indian J. Pharmacol.20104229910420711375
    [Google Scholar]
  52. SinghA. HandaS.S. Hepatoprotective activity of Apium graveolens and Hygrophila auriculata against paracetamol and thioacetamide intoxication in rats.J. Ethnopharmacol.199549311912610.1016/0378‑8741(95)01291‑58824736
    [Google Scholar]
  53. LinaS.M. AshabI. Ishtiaq AhmedM. ShahriarM. Hepatoprotective activity of Asteracantha longifolia (Nees.) extract against anti-tuberculosis drugs induced hepatic damage in Sprague-Dawley rats.Pharmacologyonline201231319
    [Google Scholar]
  54. ShivashangariK.S. RavikumarV. DevakiT. Evaluation of the protective efficacy of Asteracantha longifolia on acetaminophen-induced liver damage in rats.J. Med. Food20047224525110.1089/109662004122405815298774
    [Google Scholar]
  55. ShivashangariK.S. RavikumarV. DevakiT. GovindarajuP. Effect of Asteracantha longifolia on liver antioxidant defense system during acetaminophen-induced hepatic damage in rats.J. Clin. Biochem. Nutr.2004343899410.3164/jcbn.34.89
    [Google Scholar]
  56. MariappanA. RamalingamS. HameedS.S. SaravananR. In vivoInvestigation of hepatoprotective activity of Asteracantha Longifolia nees. on CCl4 induced hepatotoxicity in Wistar Albino Rats.Asian J. Pharm. Clin. Res.2015218222
    [Google Scholar]
  57. AbiramiN. ShanmugarajuV. MahalakshmipriyaA. RajathiK. In vitro hepatoprotective and antioxidant activities of the leaf ethanolic and aqueous extracts of Asteracantha longifolia and Andrographis paniculata against lead acetate induced toxicity.Biosci. Biotechnol. Res. Asia201761341350
    [Google Scholar]
  58. ShailajanS. ChandraN. SaneR.T. MenonS. Effect of Asteracantha longifolia Nees. against CCl4 induced liver dysfunction in rat.Indian J. Exp. Biol.2005431687515691068
    [Google Scholar]
  59. HewawasamR.P. JayatilakaK A P.W. PathiranaC. MudduwaL.K.B. Protective effect of Asteracantha longifolia extract in mouse liver injury induced by carbon tetrachloride and paracetamol.J. Pharm. Pharmacol.201055101413141810.1211/002235702179214607024
    [Google Scholar]
  60. GurusamyK. KokilavaniR. ArumuasamyK. Hepatoprotective activity of polyherbal formulation against carbon tetrachloride-induced hepatotoxicity in rats.Afr. J. Biotechnol.201094984298434
    [Google Scholar]
  61. KshirsagarA.D. AshokP. Hepatoprotective and antioxidant effects of Hygrophila spinosa (K. Schum) Heine Acanthaceae stem extract.Biosci. Biotechnol. Res. Asia201652657662
    [Google Scholar]
  62. SahooA.K. GandhareB. Effect of Hygrophila spinosa T. on reproductive function of male albino rats.J. Complement. Integr. Med.20107112010.2202/1553‑3840.1246
    [Google Scholar]
  63. VyasN.Y. RavalM.A. Aphrodisiac and spermatogenic potential of alkaloidal fraction of Hygrophila spinosa T. Ander in rats.J. Ethnopharmacol.201619419494795310.1016/j.jep.2016.10.08027989878
    [Google Scholar]
  64. VanageG. DhumalR. VijaykumarT. DigheV. SelkarN. ChawdaM. VahliaM. Efficacy and safety of a herbo-mineral ayurvedic formulation ′Afrodet Plus®′ in male rats.J. Ayurveda Integr. Med.20134315816410.4103/0975‑9476.11870624250145
    [Google Scholar]
  65. VasavaA. DaveA. varsakiyaJ. A clinical study to evaluate the role of Churna ratnam and svaguptadichurna and its effect on seminal parameters.Int. J. Res. Ayurveda Pharm.20178314514810.7897/2277‑4343.083187
    [Google Scholar]
  66. DalalP.K. TripathiA. GuptaS.K. Vajikarana: Treatment of sexual dysfunctions based on Indian concepts.Indian J. Psychiatry2013556Suppl. 227310.4103/0019‑5545.10555023858267
    [Google Scholar]
  67. HussainS.A. HameedA. NasirF. WuY. SuleriaH.A.R. SongY. Evaluation of the spermatogenic activity of polyherbal formulation in oligospermic males.BioMed Res. Int.2018201811010.1155/2018/207089530148161
    [Google Scholar]
  68. VyasN. GamitK. RavalM. Aphrodisiac and Spermatogenic Potential Of Unsaponifiable Fraction From Seeds Of Hygrophila spinosaT. Ander In Rats.Int. J. Pharm. Sci. Res.2020111049024909
    [Google Scholar]
  69. DominicS. PadmajaV. Protective Effect of An Herbal Extract in Amlodipine Induced Testicular Dysfunction In Rats. Infertility.Hygeia: J. for Drugs and Medicines2017912242
    [Google Scholar]
  70. DominicS PadmajaV Preliminary study on the altered expression of 3β HSD gene in rat testis after Amlodipine and its modification by Astercantha longifolia seed extract.Hygeia: J. for drugs and medicines.201461611
    [Google Scholar]
  71. ChauhanN.S. SharmaV. DixitV.K. Effect of Asteracantha longifolia seeds on the sexual behaviour of male rats.Nat. Prod. Res.201125151423143110.1080/1478641080258849319753500
    [Google Scholar]
  72. GhoshC. MallickC. Protective effect of ethanolic extract of Hygrophila auriculata seeds in cyproterone acetate-induced sexual dysfunction in male albino rats.Andrologia2020522e1348210.1111/and.1348231815317
    [Google Scholar]
  73. VyasN.Y. RavalM.A. Effect of unsaponifiable fraction of seeds of Hygrophila spinosa T. Ander on testosterone production of rat Leydig cells in vitro. Asian J. Pharm. Clin. Res.20169618418610.22159/ajpcr.2016.v9i6.14049
    [Google Scholar]
  74. LiuY. ChenY. LiaoB. LuoD. WangK. LiH. ZengG. Epidemiology of urolithiasis in Asia.Asian J. Urol.20185420521410.1016/j.ajur.2018.08.00730364478
    [Google Scholar]
  75. SathishR. NatarajanK. NikhadM.M. Effect of Hygrophila spinosa T. anders on ethylene glycol induced urolithiasis in rats.Asian J. Pharm. Clin. Res.2010346163
    [Google Scholar]
  76. IngaleK. ThakurdesaiP. VyawahareN. Effect of Hygrophila spinosa in ethylene glycol induced nephrolithiasis in rats.Indian J. Pharmacol.201244563964210.4103/0253‑7613.10040223112429
    [Google Scholar]
  77. ShirfuleA.L. KhobragadeC.N. BadrinarayanP. BorseY.S. AmilkanthwarR.H. Phytochemical analysis and antiurolithiatic activity of a polyherbal formulation.J. Herbs Spices Med. Plants2009151667210.1080/10496470902787493
    [Google Scholar]
  78. ShirfuleA.L. RacharlaV. QadriS.S.Y.H. KhandareA.L. Exploring antiurolithic effects of gokshuradi polyherbal ayurvedic formulation in ethylene-glycol-induced urolithic rats.Evid. Based Complement. Alternat. Med.201320131910.1155/2013/76372023554833
    [Google Scholar]
  79. HardikK.S. VrushaliV.P. JitendraD.V. VandanaB.P. GhanshyamR.P. Pharmacological evaluation of anti-urolithiatic activity of UCEX01-a herbo-mineral Ayurvedic formulation.J. Pharm. Biomed. Sci.20133518341839
    [Google Scholar]
  80. ThangarathinamN. JayshreeN. MethaA.V. RamanathanL. Development, standardization and evaluation of a polyherbal syrup.Int. J. Pharm. Sci. Rev. Res.201320149154
    [Google Scholar]
  81. WrightC.I. Van-BurenL. KronerC.I. KoningM.M.G. Herbal medicines as diuretics: A review of the scientific evidence.J. Ethnopharmacol.2007114113110.1016/j.jep.2007.07.02317804183
    [Google Scholar]
  82. HussainS. AhmedN. AnsariZ. Preliminary studies on diuretic effect of Hygrophila auriculata (Schum) Heine in rats.Int. J. of Health Res2009215964
    [Google Scholar]
  83. BabarV.B. Comparative diuretic study of medicinal plants in individual and combination form.PharmaTutor2017544245
    [Google Scholar]
  84. PatraA. JhaS. MurthyP.N. Diuretic activity of different extracts of leaves of Hygrophila spinosaT. Anders (Acanthaceae).Indian Drugs201148075053
    [Google Scholar]
  85. KumarT. ChandrashekarK.S. TripathiD.K. NagoriK. PureS. AgrawalS. TamsilA.J. Standardization of “GokshuradiChurna”: An ayurvedic polyherbal formulation.J. Chem. Pharm. Res.201133742749
    [Google Scholar]
  86. Al DisiS.S. AnwarM.A. EidA.H. Anti-hypertensive herbs and their mechanisms of action: Part I.Front. Pharmacol.2016632310.3389/fphar.2015.0032326834637
    [Google Scholar]
  87. IngaleK.G. VyawahareN.S. GautamD.T. BaviskarN.D. BakalR.L. The Antihypertensive effect of methanolic extract of Hygrophila spinosain Rats.Int. Res. J. Pharm. Appl. Sci.201444710
    [Google Scholar]
  88. VijayakumarM. GovindarajanR. RaoG.M.M. RaoC.V. ShirwaikarA. MehrotraS. PushpangadanP. Action of Hygrophila auriculata against streptozotocin-induced oxidative stress.J. Ethnopharmacol.2006104335636110.1016/j.jep.2005.09.03016289604
    [Google Scholar]
  89. MuthulingamM. Antidiabetic efficacy of leaf extracts of Asteracantha longifolia (Linn.) Nees. on alloxan induced diabetics in male albino wistar rats.Int. J. Pharm. Biomed. Res.2010122834
    [Google Scholar]
  90. ThorveV.S. KshirsagarA.D. VyawahareN.S. ThakurdesaiP.A. BhandareA.M. Hygrophila spinosa T. Anders ameliorates diabetic neuropathy in wistar albino rats.J. Complement. Integr. Med.20129111710.1515/1553‑3840.1545
    [Google Scholar]
  91. RastogiA. ShankarS. MahalingamG. Antidiabetic activity of methanolic extract of Hygrophila auriculata in adult male wistar rats.J. of Pharm. Sci. and Res20157398
    [Google Scholar]
  92. DossA. AnandS.P. Evaluation of anti-diabetic activity of methanol and aqueous extract of Astercantha longifolia (Linn) Nees.Res. J. of Phrmacol20148115
    [Google Scholar]
  93. RastogiA. ShankarS.R. MahalingamG.A. Phytochemical screening, antioxidant activity and in vitro anti-diabetic activity of aqueous, methanolic, ethanolic and chloroformic extracts of Hygrophila auriculata. Int. J. Pharm. Pharm. Sci.201465557560
    [Google Scholar]
  94. FernandoM.R. WickramasingheS.M.D.N. ThabrewM.I. Extra pancreatic actions of Hygrophila longifolia. Pharm. Biol.199836535235610.1076/phbi.36.5.352.4659
    [Google Scholar]
  95. VenugopalanP. NimishaC.N. Antioxidant and antibacterial activity of Hygrophila spinosa T Anders root extracts.Asian J. Pharm. Pharmacol.20195595996310.31024/ajpp.2019.5.5.15
    [Google Scholar]
  96. IslamM.S. ParvinM.S. IslamM.E. The protective and antioxidant effects of Hygrophila schulli seeds on oxidative damage of DNA and RBC cellular membrane.Heliyon202281e0876710.1016/j.heliyon.2022.e0876735146152
    [Google Scholar]
  97. AnushaP. ImmanuelS.R. Antioxidant and antibacterial activities of leaves extract of Hygrophila auriculata (Schumach.) Heine.J. Pharmacogn. Phytochem.20198217841789
    [Google Scholar]
  98. RaamanN. Antioxidant activites and phytochemical analysis of methanol extract of leaves of Hygrophila auriculata (Schumach) heine.Int. J. Curr. Pharm. Res.201574100105
    [Google Scholar]
  99. VijayakumarM. GovindarajanR. ShirwaikarA. KumarV. RawatA.K. MehrotraS. PushpangadanP. Free radical scavenging, and lipid peroxidation inhibition potential of Hygrophila auriculata. Nat. Prod. Sci.20051112226
    [Google Scholar]
  100. HussainM.S. AhamedK.F. RavichandiranV. AnsariM.Z. Evaluation of in vitro free radical scavenging potential of different fractions of Hygrophila auriculata (K. Schum) Heine.Asian J. Tradit. Med.200945179187
    [Google Scholar]
  101. SridharM.P. NandakumarN. RengarajanT. BalasubramanianM.P. Amelioration of mercuric chloride induced oxidative stress by Hygrophila auriculata (K. Schum) Heine via modulating the oxidant-antioxidant imbalance in rat liver.J. Biochem. Technol.201343622627
    [Google Scholar]
  102. DeSantisC.E. LinC.C. MariottoA.B. SiegelR.L. SteinK.D. KramerJ.L. AlteriR. RobbinsA.S. JemalA. Cancer treatment and survivorship statistics, 2014.CA Cancer J. Clin.201464425227110.3322/caac.2123524890451
    [Google Scholar]
  103. UddinS.J. GriceI.D. TiralongoE. Cytotoxic effects of Bangladeshi medicinal plant extracts.Evid. Based Complement. Alternat. Med.201120111710.1093/ecam/nep11119706693
    [Google Scholar]
  104. BhattacharyaS. PrasannaA. MajumdarP. KumarR.B. HaldarP.K. Antitumor efficacy and amelioration of oxidative stress by Trichosanthes dioica root against Ehrlich ascites carcinoma in mice.Pharm. Biol.201149992793521819262
    [Google Scholar]
  105. MazumdarU.K. GuptaM. MaitiS. MukherjeeD. Antitumor activity of Hygrophila spinosa on Ehrlich ascites carcinoma and sarcoma-180 induced mice.Indian J. Exp. Biol.19973554734779378516
    [Google Scholar]
  106. PattanayakS.P. SunitaP. Antitumor potency and toxicology of an Indian Ayurvedic plant, Hygrophila spinosa. Pharmacologyonline200821361371
    [Google Scholar]
  107. LamprontiI. KhanM. BianchiN. AtherA. BorgattiM. VizzielloL. FabbriE. GambariR. Bangladeshi medicinal plant extracts inhibiting molecular interactions between nuclear factors and target DNA sequences mimicking NF-kappaB binding sites.Med. Chem.20051432733310.2174/157340605436868416789890
    [Google Scholar]
  108. NabereO. SamsonG. AdamaH. MoussaC. EricS.P. AminataN.P. JeanneM.R. GermaineN.O. Antioxidant, and anticancer activities of polyphenolic compounds from three Acanthaceae medicinal species from Burkina Faso.Int. J. Phytomed.201244552
    [Google Scholar]
  109. AhmedS. RahmanA. MathurM. AtharM. SultanaS. Anti-tumor promoting activity of Asteracantha longifolia against experimental hepatocarcinogenesis in rats.Food Chem. Toxicol.2001391192810.1016/S0278‑6915(00)00103‑411259848
    [Google Scholar]
  110. NairD. ShridharN.B. JayakumarK. Evaluation of anticancer activity of Asteracantha longifolia in 7,12-Dimethylbenz(a)anthracene-induced mammary gland carcinogenesis in Sprague Dawley rats.Int. J. Nutr. Pharmacol. Neurol. Dis.2015512810.4103/2231‑0738.150072
    [Google Scholar]
  111. SatpathyS. PatraA. HussainM.D. AhirwarB. Amelioration of postmenopausal osteoporosis and anticancer properties of an antioxidant enriched fraction from Hygrophila spinosa T. Anders.S. Afr. J. Bot.201811724725510.1016/j.sajb.2018.05.033
    [Google Scholar]
  112. PatraA. JhaS. MurthyP. SatpathyS. KumarT. Preliminary phytochemical screening and antipyretic activity of leaf and root of Hygrophila SpinosaT.Anders.Pharmacologyonline20091449453
    [Google Scholar]
  113. PatraA. JhaS. MurthyP.N. VaibhavA.D. ChattopadhyayP. PanigrahiG. RoyD. Anti-inflammatory and antipyretic activities of Hygrophilaspinosa T. Anders leaves (Acanthaceae).Trop. J. Pharm. Res.20098213313710.4314/tjpr.v8i2.44521
    [Google Scholar]
  114. ShettyS.C. BhagatV.C. KoreK.J. SheteR.V. Screening of Astercantha Longifolia nees for it’s anti-inflammatory activity.Indian Drugs2008453215
    [Google Scholar]
  115. Sunil KumarK.N. DivyaK.G. MattummalR. ErniB. SathiyarajeswaranP. KanakavalliK. Pharmacological actions of contents of kabasura kudineer: a siddha formulation for fever with respiratory illness.Indian J. Pharm. Edu. Res.2021551365510.5530/ijper.55.1.7
    [Google Scholar]
  116. TekuluG.H. DestaA. HibenM.G. ArayaE.M. Anti-nociceptive and anti-inflammatory activity of hygrophila schulli leaves.J. Inflamm. Res.20201349750510.2147/JIR.S26971732943902
    [Google Scholar]
  117. LinY. ShiR. WangX. ShenH.M. Luteolin, a flavonoid with potential for cancer prevention and therapy.Curr. Cancer Drug Targets20088763464610.2174/15680090878624105018991571
    [Google Scholar]
  118. AmbroseGO AfeesOJ NwamakaNC SimonN OluwaseunAA SoyinkaT OluwaseunAS BankoleS Selection of Luteolin as a potential antagonist from molecular docking analysis of EGFR mutant.Bioinformation201814524124710.6026/97320630014241
    [Google Scholar]
  119. BagliE. StefaniotouM. MorbidelliL. ZicheM. PsillasK. MurphyC. FotsisT. Luteolin inhibits vascular endothelial growth factor-induced angiogenesis; inhibition of endothelial cell survival and proliferation by targeting phosphatidylinositol 3′-kinase activity.Cancer Res.200464217936794610.1158/0008‑5472.CAN‑03‑310415520200
    [Google Scholar]
  120. SaleemM. Lupeol, a novel anti-inflammatory and anti-cancer dietary triterpene.Cancer Lett.2009285210911510.1016/j.canlet.2009.04.03319464787
    [Google Scholar]
  121. BoparaiA. NiaziJ. BajwaN. Betulin a pentacyclic tri–terpenoid: an hour to rethink the compound.Open Access J. Trans. Med. Res2017125359
    [Google Scholar]
  122. BhattM.H. PrajapatiC.K. ReddyM.N. In silico docking studies of Lupeol with MAPK pathway proteins- Raf-1, MEK & ERK.J. Exp. Ther. Oncol.201712213714029161781
    [Google Scholar]
  123. AhmedD. KumarV. SharmaM. VermaA. Target guided isolation, in-vitro antidiabetic, antioxidant activity and molecular docking studies of some flavonoids from Albizzia Lebbeck Benth. bark.BMC Complement. Altern. Med.201414115510.1186/1472‑6882‑14‑15524886138
    [Google Scholar]
  124. MalikA. JamilU. ButtT.T. WaquarS. GanS.H. ShafiqueH. JafarT.H. In silico and in vitro studies of lupeol and iso-orientin as potential antidiabetic agents in a rat model.Drug Des. Devel. Ther.2019131501151310.2147/DDDT.S17669831123393
    [Google Scholar]
  125. GurupriyaS. CathrineL. Molecular docking studies of isolated compounds andrographolide and betulin from methanolic leaves extract of andrographis echioides as alpha-amylase and alpha-glucosidase activators.Int. J. Of Appl. Pharm.2021121129
    [Google Scholar]
  126. ChigurupatiS. Al-murikhyA. AlmahmoudS.A. AlmoshariY. Saber AhmedA. VijayabalanS. Ghazi FelembanS. Raj PalanimuthuV. Molecular docking of phenolic compounds and screening of antioxidant and antidiabetic potential of Moringa oleifera ethanolic leaves extract from Qassim region, Saudi Arabia.Saudi J. Biol. Sci.202229285485910.1016/j.sjbs.2021.10.02135197753
    [Google Scholar]
  127. MaharaniM.G. LestariS.R. LukiatiB. Molecular docking studies flavonoid (quercetin, isoquercetin, and kaempferol) of single bulb garlic (Allium sativum) to inhibit lanosterol synthase as anti-hypercholesterol therapeutic strategies.AIP Conference Proceedings202122311040021
    [Google Scholar]
  128. IslamB. SharmaC. AdemA. AburawiE. OjhaS. Insight into the mechanism of polyphenols on the activity of HMGR by molecular docking.Drug Des. Devel. Ther.2015994943495126357462
    [Google Scholar]
  129. SinghS.P. KonwarB.K. Molecular docking studies of quercetin and its analogues against human inducible nitric oxide synthase.Springerplus2012116910.1186/2193‑1801‑1‑6923556141
    [Google Scholar]
  130. HasanM.M. KhanZ. ChowdhuryM.S. KhanM.A. MoniM.A. RahmanM.H. In silico molecular docking and ADME/T analysis of quercetin compound with its evaluation of broad-spectrum therapeutic potential against particular diseases.Inform. Med. Unlocked20222910089410.1016/j.imu.2022.100894
    [Google Scholar]
  131. PatilA.G. PrakashJ.K. MoreS.S. ChandramohanV. ZameerF. Exploring Banana phytosterols (Beta-sitosterol) on tight junction protein (claudin) as anti-urolithiasis contributor in Drosophila: A phyto-lithomic approach.Inform. Med. Unlocked2022100905
    [Google Scholar]
  132. BaskarA.A. Al NumairK.S. Gabriel PaulrajM. AlsaifM.A. MuamarM.A. IgnacimuthuS. β-sitosterol prevents lipid peroxidation and improves antioxidant status and histoarchitecture in rats with 1,2-dimethylhydrazine-induced colon cancer.J. Med. Food201215433534310.1089/jmf.2011.178022353013
    [Google Scholar]
  133. ManjuV. BalasubramaniyanV. NaliniN. Rat colonic lipid peroxidation and antioxidant status: the effects of dietary luteolin on 1,2-dimethylhydrazine challenge.Cell. Mol. Biol. Lett.200510353555116217561
    [Google Scholar]
  134. DuhanJ.S. KumarR. KumarN. KaurP. NehraK. DuhanS. Nanotechnology: The new perspective in precision agriculture.Biotechnol. Rep.201715112310.1016/j.btre.2017.03.00228603692
    [Google Scholar]
  135. SatpathyS. PatraA. AhirwarB. HussainM.D. Process optimization for green synthesis of gold nanoparticles mediated by extract of Hygrophila spinosa T. Anders and their biological applications.Physica E2020121113830
    [Google Scholar]
  136. KoperuncholanM. Bioreduction of chloroauric acid (HAuCl4) for the synthesis of gold nanoparticles (GNPs): Special empathies of pharmacological activity.Int. J. Phytopharm2015547280
    [Google Scholar]
  137. DasP. ParidaU.K. Starch coatedgold nanoparticles using hygrophila auriculata L for controlled released of anticancer drug doxorubicin.Int. J. Pharma Bio Sci.201784B307B31310.22376/ijpbs.2017.8.4.b307‑313
    [Google Scholar]
  138. KowsalyaE. MosaChristasK. JaqulineC.R.I. BalashanmugamP. DevasenaT. Gold nanoparticles induced apoptosis via oxidative stress and mitochondrial dysfunctions in MCF-7 breast cancer cells.Appl. Organomet. Chem.2021351e60710.1002/aoc.6071
    [Google Scholar]
  139. BharathiS. KumaranS. SureshG. RameshB. SundariM.N. Phytosynthesis of silver nanoparticles using hygrophila auriculata leaf extract and assessment of their antibacterial and antioxidant properties.Int. J. Appl. Pharm.201810611211810.22159/ijap.2018v10i6.28605
    [Google Scholar]
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